Nasal and nasopharyngeal angiocentric T-cell lymphomas

Steven P. Davison, Thomas Matthew Habermann, John G. Strickler, Richard A. DeRemee, John D. Earle, Thomas J. McDonald

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Thirty patients (24 men and 6 women) with a median age of 44.5 years who had angiocentric T-cell lymphoma were studied. The neoplastic cells in each had a T-cell phenotype. Epstein-Barr virus RNA was detected in the neoplastic cells in 29 of 30 patients. The most common presenting symptom was nasal obstruction followed by purulent rhinorrhea. Patients with early presentation had only a friable nasal or nasopharyngeal mucosa; late clinical signs included septal perforation in 40%. Twenty-one of 30 patients received radiation therapy as initial treatment; 22 of 30 patients achieved a complete remission. Fifteen patients relapsed: 10 with local recurrence and 5 with systemic disease. In long-term follow-up, 10 patients were alive and disease free, 6 patients died of unrelated causes, and 12 patients died of disease.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalLaryngoscope
Volume106
Issue number2 I
DOIs
StatePublished - Feb 1996

Fingerprint

T-Cell Lymphoma
Nose
Nasal Obstruction
Human Herpesvirus 4
Mucous Membrane
Radiotherapy
RNA
T-Lymphocytes
Phenotype
Recurrence

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Davison, S. P., Habermann, T. M., Strickler, J. G., DeRemee, R. A., Earle, J. D., & McDonald, T. J. (1996). Nasal and nasopharyngeal angiocentric T-cell lymphomas. Laryngoscope, 106(2 I), 139-143. https://doi.org/10.1097/00005537-199602000-00005

Nasal and nasopharyngeal angiocentric T-cell lymphomas. / Davison, Steven P.; Habermann, Thomas Matthew; Strickler, John G.; DeRemee, Richard A.; Earle, John D.; McDonald, Thomas J.

In: Laryngoscope, Vol. 106, No. 2 I, 02.1996, p. 139-143.

Research output: Contribution to journalArticle

Davison, SP, Habermann, TM, Strickler, JG, DeRemee, RA, Earle, JD & McDonald, TJ 1996, 'Nasal and nasopharyngeal angiocentric T-cell lymphomas', Laryngoscope, vol. 106, no. 2 I, pp. 139-143. https://doi.org/10.1097/00005537-199602000-00005
Davison SP, Habermann TM, Strickler JG, DeRemee RA, Earle JD, McDonald TJ. Nasal and nasopharyngeal angiocentric T-cell lymphomas. Laryngoscope. 1996 Feb;106(2 I):139-143. https://doi.org/10.1097/00005537-199602000-00005
Davison, Steven P. ; Habermann, Thomas Matthew ; Strickler, John G. ; DeRemee, Richard A. ; Earle, John D. ; McDonald, Thomas J. / Nasal and nasopharyngeal angiocentric T-cell lymphomas. In: Laryngoscope. 1996 ; Vol. 106, No. 2 I. pp. 139-143.
@article{fe6b6a0b5727484fbd7195c9eeb498c2,
title = "Nasal and nasopharyngeal angiocentric T-cell lymphomas",
abstract = "Thirty patients (24 men and 6 women) with a median age of 44.5 years who had angiocentric T-cell lymphoma were studied. The neoplastic cells in each had a T-cell phenotype. Epstein-Barr virus RNA was detected in the neoplastic cells in 29 of 30 patients. The most common presenting symptom was nasal obstruction followed by purulent rhinorrhea. Patients with early presentation had only a friable nasal or nasopharyngeal mucosa; late clinical signs included septal perforation in 40{\%}. Twenty-one of 30 patients received radiation therapy as initial treatment; 22 of 30 patients achieved a complete remission. Fifteen patients relapsed: 10 with local recurrence and 5 with systemic disease. In long-term follow-up, 10 patients were alive and disease free, 6 patients died of unrelated causes, and 12 patients died of disease.",
author = "Davison, {Steven P.} and Habermann, {Thomas Matthew} and Strickler, {John G.} and DeRemee, {Richard A.} and Earle, {John D.} and McDonald, {Thomas J.}",
year = "1996",
month = "2",
doi = "10.1097/00005537-199602000-00005",
language = "English (US)",
volume = "106",
pages = "139--143",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "2 I",

}

TY - JOUR

T1 - Nasal and nasopharyngeal angiocentric T-cell lymphomas

AU - Davison, Steven P.

AU - Habermann, Thomas Matthew

AU - Strickler, John G.

AU - DeRemee, Richard A.

AU - Earle, John D.

AU - McDonald, Thomas J.

PY - 1996/2

Y1 - 1996/2

N2 - Thirty patients (24 men and 6 women) with a median age of 44.5 years who had angiocentric T-cell lymphoma were studied. The neoplastic cells in each had a T-cell phenotype. Epstein-Barr virus RNA was detected in the neoplastic cells in 29 of 30 patients. The most common presenting symptom was nasal obstruction followed by purulent rhinorrhea. Patients with early presentation had only a friable nasal or nasopharyngeal mucosa; late clinical signs included septal perforation in 40%. Twenty-one of 30 patients received radiation therapy as initial treatment; 22 of 30 patients achieved a complete remission. Fifteen patients relapsed: 10 with local recurrence and 5 with systemic disease. In long-term follow-up, 10 patients were alive and disease free, 6 patients died of unrelated causes, and 12 patients died of disease.

AB - Thirty patients (24 men and 6 women) with a median age of 44.5 years who had angiocentric T-cell lymphoma were studied. The neoplastic cells in each had a T-cell phenotype. Epstein-Barr virus RNA was detected in the neoplastic cells in 29 of 30 patients. The most common presenting symptom was nasal obstruction followed by purulent rhinorrhea. Patients with early presentation had only a friable nasal or nasopharyngeal mucosa; late clinical signs included septal perforation in 40%. Twenty-one of 30 patients received radiation therapy as initial treatment; 22 of 30 patients achieved a complete remission. Fifteen patients relapsed: 10 with local recurrence and 5 with systemic disease. In long-term follow-up, 10 patients were alive and disease free, 6 patients died of unrelated causes, and 12 patients died of disease.

UR - http://www.scopus.com/inward/record.url?scp=0030035034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030035034&partnerID=8YFLogxK

U2 - 10.1097/00005537-199602000-00005

DO - 10.1097/00005537-199602000-00005

M3 - Article

VL - 106

SP - 139

EP - 143

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 2 I

ER -