Nasal and nasopharyngeal angiocentric T-Cell lymphomas

Steven P. Davison, Thomas M. Habermann, John G. Strickler, Richard A. DeRemee, John D. Earle, Thomas J. McDonald

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Thirty patients (24 men and 6 women) with a median age of 44.5 years who had angiocentric T-cell lymphoma were studied. The neoplastic cells in each had a T-cell phenotype. Epstein-Barr virus RNA was detected in the neoplastic cells in 29 of 30 patients. The most common presenting symptom was nasal obstruction followed by purulent rhinorrhea. Patients with early presentation had only a friable nasal or nasopharyngeal mucosa; late clinical signs included septal perforation in 40%. Twenty-one of 30 patients received radiation therapy as initial treatment; 22 of 30 patients achieved a complete remission. Fifteen patients relapsed: 10 with local recurrence and 5 with systemic disease. In long-term follow-up, 10 patients were alive and disease free, 6 patients died of unrelated causes, and 12 patients died of disease.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalLaryngoscope
Volume106
Issue number2
DOIs
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Otorhinolaryngology

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