Nanotherapeutics using all-natural materials. Effective treatment of wound biofilm infections using crosslinked nanoemulsions

Cheng Hsuan Li, Ryan F. Landis, Jessa Marie Makabenta, Ahmed Nabawy, Tiphaine Tronchet, Danielle Archambault, Yuanchang Liu, Rui Huang, Morgane Golan, Wei Cui, Jesse Mager, Akash Gupta, Suzannah Schmidt-Malan, Robin Patel, Vincent M. Rotello

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial wound infections are a threat to public health. Although antibiotics currently provide front-line treatments for bacterial infections, the development of drug resistance coupled with the defenses provided through biofilm formation render these infections difficult, if not impossible, to cure. Antimicrobials from natural resources provide unique antimicrobial mechanisms and are generally recognized as safe and sustainable. Herein, an all-natural antimicrobial platform is reported. It is active against bacterial biofilms and accelerates healing of wound biofilm infections in vivo. This antimicrobial platform uses gelatin stabilized by photocrosslinking using riboflavin (vitamin B2) as a photocatalyst, and carvacrol (the primary constituent of oregano oil) as the active antimicrobial. The engineered nanoemulsions demonstrate broad-spectrum antimicrobial activity towards drug-resistant bacterial biofilms and significantly expedite wound healing in an in vivo murine wound biofilm model. The antimicrobial activity, wound healing promotion, and biosafety of these nanoemulsions provide a readily translatable and sustainable strategy for managing wound infections. This journal is

Original languageEnglish (US)
Pages (from-to)1776-1782
Number of pages7
JournalMaterials Horizons
Volume8
Issue number6
DOIs
StatePublished - Jun 2021

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Process Chemistry and Technology
  • Electrical and Electronic Engineering

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