Nanoparticles for combination drug therapy

Liang Ma, Manish Kohli, Andrew Smith

Research output: Contribution to journalReview article

188 Scopus citations

Abstract

Nanoparticles have recently emerged as a promising class of carriers for the co-delivery of multiple drugs. Combination therapies of small-molecule drugs are common in clinical practice, and it is anticipated that packaging into single macromolecular carriers will enable drug release in precisely balanced ratios and rates and in selectively targeted tissues and cells. This vast level of pharmacological control is intriguing, especially from the perspective of tailoring personalized treatments with maximized therapeutic synergy for individual patients. Here, we discuss promising formulations and opportunities to employ advanced screening tools and new animal models of disease that can improve chances for successful clinical translation.

Original languageEnglish (US)
Pages (from-to)9518-9525
Number of pages8
JournalACS Nano
Volume7
Issue number11
DOIs
StatePublished - Nov 26 2013

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Nanoparticles for combination drug therapy'. Together they form a unique fingerprint.

  • Cite this

    Ma, L., Kohli, M., & Smith, A. (2013). Nanoparticles for combination drug therapy. ACS Nano, 7(11), 9518-9525. https://doi.org/10.1021/nn405674m