Nanoparticle-Mediated Drug Delivery for Treatment of Ischemic Heart Disease

Chengming Fan, Jyotsna Joshi, Fan Li, Bing Xu, Mahmood Khan, Jinfu Yang, Wuqiang Zhu

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The regenerative capacity of an adult cardiac tissue is insufficient to repair the massive loss of heart tissue, particularly cardiomyocytes (CMs), following ischemia or other catastrophic myocardial injuries. The delivery methods of therapeutics agents, such as small molecules, growth factors, exosomes, cells, and engineered tissues have significantly advanced in medical science. Furthermore, with the controlled release characteristics, nanoparticle (NP) systems carrying drugs are promising in enhancing the cardioprotective potential of drugs in patients with cardiac ischemic events. NPs can provide sustained exposure precisely to the infarcted heart via direct intramyocardial injection or intravenous injection with active targets. In this review, we present the recent advances and challenges of different types of NPs loaded with agents for the repair of myocardial infarcted heart tissue.

Original languageEnglish (US)
Article number687
JournalFrontiers in Bioengineering and Biotechnology
Volume8
DOIs
StatePublished - Jun 24 2020

Keywords

  • cardiac repair
  • controlled release
  • drug delivery systems
  • myocardial infarction
  • nanoparticles

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Histology
  • Biomedical Engineering

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