Nanoparticle-mediated cellular response is size-dependent

Wen Jiang, Y S Betty Kim, James T. Rutka, Warren C W Chan

Research output: Contribution to journalArticle

1735 Citations (Scopus)

Abstract

Nanostructures of different sizes, shapes and material properties have many applications in biomedical imaging, clinical diagnostics and therapeutics. In spite of what has been achieved so far, a complete understanding of how cells interact with nanostructures of well-defined sizes, at the molecular level, remains poorly understood. Here we show that gold and silver nanoparticles coated with antibodies can regulate the process of membrane receptor internalization. The binding and activation of membrane receptors and subsequent protein expression strongly depend on nanoparticle size. Although all nanoparticles within the 2-100 nm size range were found to alter signalling processes essential for basic cell functions (including cell death), 40- and 50-nm nanoparticles demonstrated the greatest effect. These results show that nanoparticles should no longer be viewed as simple carriers for biomedical applications, but can also play an active role in mediating biological effects. The findings presented here may assist in the design of nanoscale delivery and therapeutic systems and provide insights into nanotoxicity.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalNature Nanotechnology
Volume3
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Nanoparticles
nanoparticles
Nanostructures
membranes
Membranes
biological effects
Medical imaging
Cell death
cells
antibodies
Silver
Antibodies
death
Gold
delivery
Materials properties
Chemical activation
silver
activation
gold

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Nanoparticle-mediated cellular response is size-dependent. / Jiang, Wen; Kim, Y S Betty; Rutka, James T.; Chan, Warren C W.

In: Nature Nanotechnology, Vol. 3, No. 3, 03.2008, p. 145-150.

Research output: Contribution to journalArticle

Jiang, Wen ; Kim, Y S Betty ; Rutka, James T. ; Chan, Warren C W. / Nanoparticle-mediated cellular response is size-dependent. In: Nature Nanotechnology. 2008 ; Vol. 3, No. 3. pp. 145-150.
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