Abstract
Hierarchical organization and specialized composition of bone extracellular matrix (ECM) control the cellular processes including proliferation, migration, and differentiation for continuous modulation and maintenance of structure. For bone tissue regeneration, peptideor polymer-based biomaterials have offered a framework to design interactive molecules displaying bone composite properties to mimic living bone tissue. This chapter reviews the structure and properties of peptide- and polymer-based soft grafts for bone tissue regeneration, with a summary of upcoming goals and challenges in the future of these versatile materials. It basically covers types and applications of soft bone grafts, directed bone regeneration from biocompatible and bioactive biomaterials, and nanocomposite scaffolds for bone tissue regeneration. Bone regeneration studies have been primarily focused on polymers and synthetic proteins. The chapter describes some of the significant contribcutions to the field of bone regeneration with self-assembled peptide structures.
| Original language | English (US) |
|---|---|
| Title of host publication | Therapeutic Nanomaterials |
| Publisher | wiley |
| Pages | 119-151 |
| Number of pages | 33 |
| ISBN (Electronic) | 9781118987483 |
| ISBN (Print) | 9781118987452 |
| DOIs | |
| State | Published - Jan 1 2016 |
Keywords
- Adult tissue
- Bioactivity
- Bone matrix
- Bone tissue regeneration
- Inorganic matrix
- Mineralization
- Nanocomposite scaffolds
- Organic matrix
- Orthopedic implants
ASJC Scopus subject areas
- General Engineering
- General Materials Science
- General Medicine
- General Biochemistry, Genetics and Molecular Biology