Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

Jessa Marie V. Makabenta, Ahmed Nabawy, Cheng Hsuan Li, Suzannah Schmidt-Malan, Robin Patel, Vincent M. Rotello

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative ‘outside of the box’ therapeutics. Nanomaterial-based therapies are promising tools to combat bacterial infections that are difficult to treat, featuring the capacity to evade existing mechanisms associated with acquired drug resistance. In addition, the unique size and physical properties of nanomaterials give them the capability to target biofilms, overcoming recalcitrant infections. In this Review, we highlight the general mechanisms by which nanomaterials can be used to target bacterial infections associated with acquired antibiotic resistance and biofilms. We emphasize design elements and properties of nanomaterials that can be engineered to enhance potency. Lastly, we present recent progress and remaining challenges for widespread clinical implementation of nanomaterials as antimicrobial therapeutics.

Original languageEnglish (US)
Pages (from-to)23-36
Number of pages14
JournalNature Reviews Microbiology
Volume19
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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