Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus

Myoung Hwa Lee, Hong Kim, Baek Vin Lim, Hyun Kyung Chang, Taeck Hyun Lee, Mi-Hyeon D Jang, Min Chul Shin, Jongseok Lee, Mal Soon Shin, Chang Ju Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The expression of c-Fos is induced by a variety of stimuli and is sometimes used as a marker for increased neuronal activity. In the present study, the effect of treadmill running on c-Fos expression in the hippocampus and the involvement of opioid receptors were investigated via c-Fos immunohistochemistry. It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression. Base on the present results, it can be suggested that treadmill running increases hippocamal neuronal activity and that endogenous opioids curtail the exercise-induced increase.

Original languageEnglish (US)
Pages (from-to)3139-3147
Number of pages9
JournalLife Sciences
Volume73
Issue number24
DOIs
StatePublished - Oct 31 2003
Externally publishedYes

Fingerprint

Exercise equipment
Naloxone
Running
Rats
Hippocampus
Parahippocampal Gyrus
Narcotic Antagonists
Dentate Gyrus
Opioid Receptors
Opioid Analgesics
Immunohistochemistry
Therapeutics

Keywords

  • c-Fos immunohistochemistry
  • Hippocampus
  • Naloxone
  • Treadmill exercise

ASJC Scopus subject areas

  • Pharmacology

Cite this

Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus. / Lee, Myoung Hwa; Kim, Hong; Lim, Baek Vin; Chang, Hyun Kyung; Lee, Taeck Hyun; Jang, Mi-Hyeon D; Shin, Min Chul; Lee, Jongseok; Shin, Mal Soon; Kim, Chang Ju.

In: Life Sciences, Vol. 73, No. 24, 31.10.2003, p. 3139-3147.

Research output: Contribution to journalArticle

Lee, MH, Kim, H, Lim, BV, Chang, HK, Lee, TH, Jang, M-HD, Shin, MC, Lee, J, Shin, MS & Kim, CJ 2003, 'Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus', Life Sciences, vol. 73, no. 24, pp. 3139-3147. https://doi.org/10.1016/j.lfs.2003.06.005
Lee, Myoung Hwa ; Kim, Hong ; Lim, Baek Vin ; Chang, Hyun Kyung ; Lee, Taeck Hyun ; Jang, Mi-Hyeon D ; Shin, Min Chul ; Lee, Jongseok ; Shin, Mal Soon ; Kim, Chang Ju. / Naloxone potentiates treadmill running-induced increase in c-Fos expression in rat hippocampus. In: Life Sciences. 2003 ; Vol. 73, No. 24. pp. 3139-3147.
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