TY - JOUR
T1 - Nab-paclitaxel in patients with metastatic melanoma
AU - Leon-Ferre, Roberto A.
AU - Markovic, Svetomir N.
N1 - Publisher Copyright:
© 2015 Taylor and Francis.
PY - 2015/12/2
Y1 - 2015/12/2
N2 - Cutaneous melanoma is one of the most aggressive and resistant malignancies in humans. Until recently, progress in the treatment of metastatic melanoma remained dormant for nearly two decades. However, recent advances in immune and targeted therapeutic approaches have led to dramatic and paradigm-shifting advances in the management of metastatic melanoma, that are now leading the way for other malignancies. With the advent of these new therapeutic options, chemotherapy is no longer favored as a first line strategy in metastatic melanoma, but continues to play a role in the salvage treatment of patients that have become refractory to immune-based or targeted therapies. Nab-paclitaxel, a solvent-free alternative to solvent-based paclitaxel, has shown in several trials to be active in metastatic melanoma. Herein, we summarize the role of nab-paclitaxel in the management of patients with advanced melanoma.
AB - Cutaneous melanoma is one of the most aggressive and resistant malignancies in humans. Until recently, progress in the treatment of metastatic melanoma remained dormant for nearly two decades. However, recent advances in immune and targeted therapeutic approaches have led to dramatic and paradigm-shifting advances in the management of metastatic melanoma, that are now leading the way for other malignancies. With the advent of these new therapeutic options, chemotherapy is no longer favored as a first line strategy in metastatic melanoma, but continues to play a role in the salvage treatment of patients that have become refractory to immune-based or targeted therapies. Nab-paclitaxel, a solvent-free alternative to solvent-based paclitaxel, has shown in several trials to be active in metastatic melanoma. Herein, we summarize the role of nab-paclitaxel in the management of patients with advanced melanoma.
KW - Melanoma
KW - albumin-bound paclitaxel
KW - cremophore free paclitaxel
KW - nab-paclitaxel
KW - solvent-free paclitaxel
KW - taxanes
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U2 - 10.1586/14737140.2015.1110024
DO - 10.1586/14737140.2015.1110024
M3 - Article
C2 - 26536477
AN - SCOPUS:84949320076
SN - 1473-7140
VL - 15
SP - 1371
EP - 1377
JO - Expert review of anticancer therapy
JF - Expert review of anticancer therapy
IS - 12
ER -