N-substituted cyclopropylamines as inhibitors of MAO-A and -B forms

Dennis L. Murphy, Cynthia H. Donnelly, Elliott Richelson, Ray W. Fuller

Research output: Contribution to journalArticle

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Abstract

Monoamine oxidase (MAO) activity in mouse neuroblastoma homogenates was preferentially inhibited by N[2-(o-chlorophenoxy)-ethyl]cyclopropylamine (L-51641) and a series of structurally related compounds. Two other congeners (L-54761 and L-54748) from this series, however, demonstrated preferential inhibition of MAO in human platelet homogenates. As neuroblastoma and human platelet cells have been identified as possessing apparently exclusive MAO-A and MAO-B characteristics, respectively, L-54761 and L-54748 appear to be preferential MAO-B inhibitors. In keeping with this conclusion, a greater proportional inhibition of phenylethylamine oxidation than serotonin oxidation by these two compounds was found in rat brain homogenates, while contrasting results were obtained with L-51641. Preferential effects of L-54761 and L-51641 on phenylethylamine oxidation and, to a lesser extent, on serotonin oxidation were also observed in vivo.

Original languageEnglish (US)
Pages (from-to)1767-1769
Number of pages3
JournalBiochemical Pharmacology
Volume27
Issue number13
DOIs
StatePublished - 1978
Externally publishedYes

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Monoamine Oxidase
Phenethylamines
Oxidation
Platelets
Neuroblastoma
Serotonin
Blood Platelets
Monoamine Oxidase Inhibitors
Rats
Brain
cyclopropylamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Murphy, D. L., Donnelly, C. H., Richelson, E., & Fuller, R. W. (1978). N-substituted cyclopropylamines as inhibitors of MAO-A and -B forms. Biochemical Pharmacology, 27(13), 1767-1769. https://doi.org/10.1016/0006-2952(78)90554-3

N-substituted cyclopropylamines as inhibitors of MAO-A and -B forms. / Murphy, Dennis L.; Donnelly, Cynthia H.; Richelson, Elliott; Fuller, Ray W.

In: Biochemical Pharmacology, Vol. 27, No. 13, 1978, p. 1767-1769.

Research output: Contribution to journalArticle

Murphy, DL, Donnelly, CH, Richelson, E & Fuller, RW 1978, 'N-substituted cyclopropylamines as inhibitors of MAO-A and -B forms', Biochemical Pharmacology, vol. 27, no. 13, pp. 1767-1769. https://doi.org/10.1016/0006-2952(78)90554-3
Murphy, Dennis L. ; Donnelly, Cynthia H. ; Richelson, Elliott ; Fuller, Ray W. / N-substituted cyclopropylamines as inhibitors of MAO-A and -B forms. In: Biochemical Pharmacology. 1978 ; Vol. 27, No. 13. pp. 1767-1769.
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