N-acetylaspartate normalization in bipolar depression after lamotrigine treatment

Paul E. Croarkin, M. Albert Thomas, John D. Port, Joshua M. Baruth, Doo Sup Choi, Osama A. Abulseoud, Mark A. Frye

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objectives: The aim of the present study was to examine N-acetylaspartate (NAA), a general marker of neuronal viability, and total NAA (tNAA), the combined signal of NAA and N-acetylaspartylglutamate, in bipolar depression before and after lamotrigine treatment. Given that NAA is synthesized through direct acetylation of aspartate by acetyl-coenzyme A-l-aspartate-N-acetyltransferase, we hypothesized that treatment with lamotrigine would be associated with an increase in NAA level. Methods: Patients with bipolar depression underwent two-dimensional proton magnetic resonance spectroscopy of the anterior cingulate at baseline (n = 15) and after 12 weeks of lamotrigine treatment (n = 10). A group of age-matched healthy controls (n = 9) underwent scanning at baseline for comparison. Results: At baseline, patients with bipolar depression had significantly lower NAA [mean standard deviation (SD) = 1.13 (0.21); p = 0.02] than controls [mean (SD) = 1.37 (0.27)]. Significant increases in NAA [mean (SD) = 1.39 (0.21); p = 0.01] and tNAA [mean (SD) = 1.61 (0.25); p = 0.02] levels were found after 12 weeks of lamotrigine treatment. Conclusions: These data suggest an NAA deficit in bipolar depression that is normalized after lamotrigine treatment. Future research is warranted to evaluate whether baseline NAA level is a potential biomarker for identifying lamotrigine response patterns and whether this functional brain change has an associated clinical response.

Original languageEnglish (US)
Pages (from-to)450-457
Number of pages8
JournalBipolar disorders
Volume17
Issue number4
DOIs
StatePublished - Jun 1 2015

Keywords

  • Bipolar depression
  • Bipolar disorder
  • Lamotrigine
  • N-acetylaspartate
  • Neuroprotection
  • Two-dimensional proton magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'N-acetylaspartate normalization in bipolar depression after lamotrigine treatment'. Together they form a unique fingerprint.

  • Cite this