Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality

Cristiane M. Ida; Kristen A. Rolig; Rachael L. Hulshizer; Daniel L. Van Dyke; Jamie L. Randolph; Robert B. Jenkins; Antonio G. Nascimento; Andre M. Oliveira

doi:10.1016/j.cancergencyto.2007.05.018

Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality

Cristiane M. Ida, Kristen A. Rolig, Rachael L. Hulshizer, Daniel L. Van Dyke, Jamie L. Randolph, Robert B. Jenkins, Antonio G. Nascimento, Andre M. Oliveira

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade sarcoma characterized by distinctive, large, and bizarre Reed-Sternberg-like cells associated with an intense inflammatory infiltrate. The biology of MIFS is still poorly understood, and only two previous cases had been studied cytogenetically. In the present case, analysis of MIFS in the foot of a 53-year-old man revealed the chromosome translocation t(2;6)(q31;p21.3) as the only cytogenetic abnormality. This finding is distinct from the two cases previously reported. Additional studies are needed to verify whether any of these chromosome rearrangements are involved recurrently in MIFS.

Original language	English (US)
Pages (from-to)	139-142
Number of pages	4
Journal	Cancer Genetics and Cytogenetics
Volume	177
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2007.05.018
State	Published - Sep 2007

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergencyto.2007.05.018

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title = "Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality",

abstract = "Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade sarcoma characterized by distinctive, large, and bizarre Reed-Sternberg-like cells associated with an intense inflammatory infiltrate. The biology of MIFS is still poorly understood, and only two previous cases had been studied cytogenetically. In the present case, analysis of MIFS in the foot of a 53-year-old man revealed the chromosome translocation t(2;6)(q31;p21.3) as the only cytogenetic abnormality. This finding is distinct from the two cases previously reported. Additional studies are needed to verify whether any of these chromosome rearrangements are involved recurrently in MIFS.",

author = "Ida, {Cristiane M.} and Rolig, {Kristen A.} and Hulshizer, {Rachael L.} and {Van Dyke}, {Daniel L.} and Randolph, {Jamie L.} and Jenkins, {Robert B.} and Nascimento, {Antonio G.} and Oliveira, {Andre M.}",

year = "2007",

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doi = "10.1016/j.cancergencyto.2007.05.018",

language = "English (US)",

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T1 - Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality

AU - Ida, Cristiane M.

AU - Rolig, Kristen A.

AU - Hulshizer, Rachael L.

AU - Van Dyke, Daniel L.

AU - Randolph, Jamie L.

AU - Jenkins, Robert B.

AU - Nascimento, Antonio G.

AU - Oliveira, Andre M.

PY - 2007/9

Y1 - 2007/9

N2 - Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade sarcoma characterized by distinctive, large, and bizarre Reed-Sternberg-like cells associated with an intense inflammatory infiltrate. The biology of MIFS is still poorly understood, and only two previous cases had been studied cytogenetically. In the present case, analysis of MIFS in the foot of a 53-year-old man revealed the chromosome translocation t(2;6)(q31;p21.3) as the only cytogenetic abnormality. This finding is distinct from the two cases previously reported. Additional studies are needed to verify whether any of these chromosome rearrangements are involved recurrently in MIFS.

AB - Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low-grade sarcoma characterized by distinctive, large, and bizarre Reed-Sternberg-like cells associated with an intense inflammatory infiltrate. The biology of MIFS is still poorly understood, and only two previous cases had been studied cytogenetically. In the present case, analysis of MIFS in the foot of a 53-year-old man revealed the chromosome translocation t(2;6)(q31;p21.3) as the only cytogenetic abnormality. This finding is distinct from the two cases previously reported. Additional studies are needed to verify whether any of these chromosome rearrangements are involved recurrently in MIFS.

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Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality

Abstract

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