Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion

L. Silberstein, A. Davies, S. Kelsey, J. Foran, C. Murrell, D. D'Cruz, S. Vinnicombe, A. Norton, J. Cavenagh

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalBone Marrow Transplantation
Volume27
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Constrictive pericarditis
  • Graft-versus-host disease
  • Myositis
  • Pericardial effusion
  • Polyserositis

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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