Myoplasmic Ca2+ concentration during exertional rhabdomyolysis

J. R. López; M. A. Gonzalez; B. Rojas; J. R. López; A. Terzic

doi:10.1016/S0140-6736(95)90405-0

Myoplasmic Ca²⁺ concentration during exertional rhabdomyolysis

J. R. López, M. A. Gonzalez, B. Rojas, J. R. López, A. Terzic

Cardiovascular Medicine

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Abstract

Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca²⁺ concentration ([Ca²⁺]i) was 1·27 (0·17) μmol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0·12 (0·01) μmol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca²⁺ release from the sarcoplasmic reticulum, decreased [Ca²⁺]i to 0·22 (0·05) μmol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca²⁺]i, and that dantrolene has a beneficial effect in this syndrome.

Original language	English (US)
Pages (from-to)	424-425
Number of pages	2
Journal	The Lancet
Volume	345
Issue number	8947
DOIs	https://doi.org/10.1016/S0140-6736(95)90405-0
State	Published - Feb 18 1995

ASJC Scopus subject areas

General Medicine

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title = "Myoplasmic Ca2+ concentration during exertional rhabdomyolysis",

abstract = "Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca2+ concentration ([Ca2+]i) was 1·27 (0·17) μmol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0·12 (0·01) μmol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0·22 (0·05) μmol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca2+]i, and that dantrolene has a beneficial effect in this syndrome.",

author = "L{\'o}pez, {J. R.} and Gonzalez, {M. A.} and B. Rojas and L{\'o}pez, {J. R.} and A. Terzic",

note = "Funding Information: younger, people in the response of bone mass to calcium intake and supplementation may be explained partly by the interaction between environmental and genetic factors.{\textquoteright}° Analysis of VDR-gene polymorphisms may allow better definition and prediction of these responses. We thank Mrs M N Cerutti for data collection. This work was supported by a grant from the Swiss National Science Foundation (number 32-2415-91).",

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doi = "10.1016/S0140-6736(95)90405-0",

language = "English (US)",

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AU - López, J. R.

AU - Gonzalez, M. A.

AU - Rojas, B.

AU - López, J. R.

AU - Terzic, A.

N1 - Funding Information: younger, people in the response of bone mass to calcium intake and supplementation may be explained partly by the interaction between environmental and genetic factors.’° Analysis of VDR-gene polymorphisms may allow better definition and prediction of these responses. We thank Mrs M N Cerutti for data collection. This work was supported by a grant from the Swiss National Science Foundation (number 32-2415-91).

PY - 1995/2/18

Y1 - 1995/2/18

N2 - Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca2+ concentration ([Ca2+]i) was 1·27 (0·17) μmol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0·12 (0·01) μmol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0·22 (0·05) μmol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca2+]i, and that dantrolene has a beneficial effect in this syndrome.

AB - Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca2+ concentration ([Ca2+]i) was 1·27 (0·17) μmol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0·12 (0·01) μmol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0·22 (0·05) μmol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca2+]i, and that dantrolene has a beneficial effect in this syndrome.

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JO - The Lancet

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ER -

Myoplasmic Ca²⁺ concentration during exertional rhabdomyolysis

Abstract

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