TY - JOUR
T1 - Myopathy during treatment with the antianginal drug ranolazine
AU - Kassardjian, Charles D.
AU - Tian, Xia
AU - Vladutiu, Georgirene
AU - Wong, Lee Jun
AU - Milone, Margherita
N1 - Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Ranolazine is a medication indicated for treatment of chronic angina and is a partial inhibitor of the fatty acid β-oxidation. We present an adult patient who developed subacute progressive muscle weakness and exercise-induced myalgia, soon after increasing the daily dose of ranolazine, in the setting of therapy with simvastatin. CK persisted normal throughout the duration of the weakness and muscle biopsy showed a lipid storage myopathy for which no underlying genetic defect was identified. Discontinuation of both drugs resulted in clinical improvement. Although simvastatin may have contributed to the myopathy, the temporal relation between the increase in ranolazine dose and the onset of the weakness would favor ranolazine as major culprit for the weakness.
AB - Ranolazine is a medication indicated for treatment of chronic angina and is a partial inhibitor of the fatty acid β-oxidation. We present an adult patient who developed subacute progressive muscle weakness and exercise-induced myalgia, soon after increasing the daily dose of ranolazine, in the setting of therapy with simvastatin. CK persisted normal throughout the duration of the weakness and muscle biopsy showed a lipid storage myopathy for which no underlying genetic defect was identified. Discontinuation of both drugs resulted in clinical improvement. Although simvastatin may have contributed to the myopathy, the temporal relation between the increase in ranolazine dose and the onset of the weakness would favor ranolazine as major culprit for the weakness.
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U2 - 10.1016/j.jns.2014.10.037
DO - 10.1016/j.jns.2014.10.037
M3 - Article
C2 - 25466697
AN - SCOPUS:84920199403
SN - 0022-510X
VL - 347
SP - 380
EP - 382
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 1-2
ER -