Myoneural interactions affect diaphragm muscle adaptations to inactivity

H. Miyata, W. Z. Zhan, Y.s. Prakash, Gary C Sieck

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

We hypothesized that inactivity effects on diaphragm muscle contractile and morphometric properties are attenuated if phrenic motoneurons are also inactive. Three models of rat diaphragm inactivity were compared: 1) spinal isolation; 2) tetrodotoxin (TTX) nerve blockade; and 3) denervation (Dnv). Motoneuron and muscle fiber inactivities were matched only in spinal isolated animals. After 2 wk, maximum tetanic force decreased in all three groups compared with control group but to a greater extent in TTX and Dnv animals. Fatigue resistance improved, and maximum unloaded shortening velocity slowed only in TTX and Dnv groups. Type IIa fiber proportions decreased in all three groups, and type IIx fiber proportions increased in TTX and Dnv animals. Type I fiber cross-sectional area increased in all three groups but to a greater extent in TTX and Dnv animals. Type IIa fibers hypertrophied, whereas type fix and lib fibers atrophied only in TTX and Dnv groups. These results support the hypothesis that muscle adaptations to prolonged inactivity are attenuated when muscle fiber and motoneuron inactivities are matched.

Original languageEnglish (US)
Pages (from-to)1640-1649
Number of pages10
JournalJournal of Applied Physiology
Volume79
Issue number5
StatePublished - 1995

Fingerprint

Tetrodotoxin
Denervation
Diaphragm
Muscles
Motor Neurons
Nerve Block
Fatigue
Control Groups

Keywords

  • contractility
  • disuse
  • muscle fiber
  • plasticity

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Myoneural interactions affect diaphragm muscle adaptations to inactivity. / Miyata, H.; Zhan, W. Z.; Prakash, Y.s.; Sieck, Gary C.

In: Journal of Applied Physiology, Vol. 79, No. 5, 1995, p. 1640-1649.

Research output: Contribution to journalArticle

Miyata, H. ; Zhan, W. Z. ; Prakash, Y.s. ; Sieck, Gary C. / Myoneural interactions affect diaphragm muscle adaptations to inactivity. In: Journal of Applied Physiology. 1995 ; Vol. 79, No. 5. pp. 1640-1649.
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