Myocarditis

Lori A. Blauwet, Leslie T Jr. Cooper

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Myocarditis is an uncommon, potentially life-threatening disease that presents with a wide range of symptoms in children and adults. Viral infection is the most common cause of myocarditis in developed countries, but other etiologies include bacterial and protozoal infections, toxins, drug reactions, autoimmune diseases, giant cell myocarditis, and sarcoidosis. Acute injury leads to myocyte damage, which in turn activates the innate and humeral immune system, leading to severe inflammation. In most patients, the immune reaction is eventually down-regulated and the myocardium recovers. In select cases, however, persistent myocardial inflammation leads to ongoing myocyte damage and relentless symptomatic heart failure or even death. The diagnosis is usually made based on clinical presentation and noninvasive imaging findings. Most patients respond well to standard heart failure therapy, although in severe cases, mechanical circulatory support or heart transplantation is indicated. Prognosis in acute myocarditis is generally good except in patients with giant cell myocarditis. Persistent, chronic myocarditis usually has a progressive course but may respond to immunosuppression.

Original languageEnglish (US)
Pages (from-to)274-288
Number of pages15
JournalProgress in Cardiovascular Diseases
Volume52
Issue number4
DOIs
StatePublished - Jan 2010

Fingerprint

Myocarditis
Giant Cells
Muscle Cells
Heart Failure
Inflammation
Virus Diseases
Heart Transplantation
Sarcoidosis
Bacterial Infections
Developed Countries
Immunosuppression
Autoimmune Diseases
Immune System
Myocardium
Wounds and Injuries
Pharmaceutical Preparations

Keywords

  • Dilated cardiomyopathy
  • Endomyocardial biopsy
  • Heart failure
  • Myocarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Myocarditis. / Blauwet, Lori A.; Cooper, Leslie T Jr.

In: Progress in Cardiovascular Diseases, Vol. 52, No. 4, 01.2010, p. 274-288.

Research output: Contribution to journalArticle

Blauwet, Lori A. ; Cooper, Leslie T Jr. / Myocarditis. In: Progress in Cardiovascular Diseases. 2010 ; Vol. 52, No. 4. pp. 274-288.
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