Myocarditis

Sandeep Sagar, Peter P. Liu, Leslie T Jr. Cooper

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

Myocarditis is an underdiagnosed cause of acute heart failure, sudden death, and chronic dilated cardiomyopathy. In developed countries, viral infections commonly cause myocarditis; however, in the developing world, rheumatic carditis, Trypanosoma cruzi, and bacterial infections such as diphtheria still contribute to the global burden of the disease. The short-term prognosis of acute myocarditis is usually good, but varies widely by cause. Those patients who initially recover might develop recurrent dilated cardiomyopathy and heart failure, sometimes years later. Because myocarditis presents with non-specific symptoms including chest pain, dyspnoea, and palpitations, it often mimics more common disorders such as coronary artery disease. In some patients, cardiac MRI and endomyocardial biopsy can help identify myocarditis, predict risk of cardiovascular events, and guide treatment. Finding effective therapies has been challenging because the pathogenesis of chronic dilated cardiomyopathy after viral myocarditis is complex and determined by host and viral genetics as well as environmental factors. Findings from recent clinical trials suggest that some patients with chronic inflammatory cardiomyopathy have a progressive clinical course despite standard medical care and might improve with a short course of immunosuppression.

Original languageEnglish (US)
Pages (from-to)738-747
Number of pages10
JournalThe Lancet
Volume379
Issue number9817
DOIs
StatePublished - Feb 2012

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Myocarditis
Dilated Cardiomyopathy
Heart Failure
Diphtheria
Trypanosoma cruzi
Virus Diseases
Sudden Death
Chest Pain
Cardiomyopathies
Bacterial Infections
Developed Countries
Dyspnea
Immunosuppression
Coronary Artery Disease
Clinical Trials
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Myocarditis. / Sagar, Sandeep; Liu, Peter P.; Cooper, Leslie T Jr.

In: The Lancet, Vol. 379, No. 9817, 02.2012, p. 738-747.

Research output: Contribution to journalArticle

Sagar, S, Liu, PP & Cooper, LTJ 2012, 'Myocarditis', The Lancet, vol. 379, no. 9817, pp. 738-747. https://doi.org/10.1016/S0140-6736(11)60648-X
Sagar, Sandeep ; Liu, Peter P. ; Cooper, Leslie T Jr. / Myocarditis. In: The Lancet. 2012 ; Vol. 379, No. 9817. pp. 738-747.
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