TY - JOUR
T1 - Myocardial viability independently influences left ventricular diastolic function in the early phase after acute myocardial infarction
AU - Rossi, Andrea
AU - Cicoira, Mariantonietta
AU - Anselmi, Maurizio
AU - Golia, Giorgio
AU - Latina, Loredana
AU - Tinto, Monica
AU - Zardini, Piero
AU - Oh, Jae K.
PY - 2002/12/1
Y1 - 2002/12/1
N2 - Background: After acute myocardial infarction, a broad range of left ventricular (LV) end-diastolic pressure (LVEDP) is expected because of chamber remodeling. However, intrinsic characteristics of the infarcted tissue (necrosis or viability) may also play a role. We aimed to evaluate whether myocardial viability (Mviab) has an influence on LVEDP. Methods: One hundred twenty-three consecutive patients with acute myocardial infarction underwent low-dose dobutamine echocardiography (5-10 μg/kg/min) to assess Mviab. Mviab was quantitatively evaluated by the variation of Δ wall motion score index. Patients underwent left heart catheterization with recording of LVEDP and a complete echocardiographic examination with measurement of LV volumes, ejection fraction, and mass. Results: The overall population (81% male; mean age 58 ± 10 years) was divided into 2 groups according to the presence (group 1; 66 patients) or absence (group 2; 57 patients) of Mviab. LVEDP was higher in patients without Mviab (16 ± 8 vs 20 ± 7 mm Hg; P = .02). The multivariate analysis showed that A wall motion score index correlated with LVEDP (P = .01) independent of wall motion score index and LV end-systolic volume. Conclusions: After acute myocardial infarction, LVEDP shows wide variability and is independently associated with Mviab.
AB - Background: After acute myocardial infarction, a broad range of left ventricular (LV) end-diastolic pressure (LVEDP) is expected because of chamber remodeling. However, intrinsic characteristics of the infarcted tissue (necrosis or viability) may also play a role. We aimed to evaluate whether myocardial viability (Mviab) has an influence on LVEDP. Methods: One hundred twenty-three consecutive patients with acute myocardial infarction underwent low-dose dobutamine echocardiography (5-10 μg/kg/min) to assess Mviab. Mviab was quantitatively evaluated by the variation of Δ wall motion score index. Patients underwent left heart catheterization with recording of LVEDP and a complete echocardiographic examination with measurement of LV volumes, ejection fraction, and mass. Results: The overall population (81% male; mean age 58 ± 10 years) was divided into 2 groups according to the presence (group 1; 66 patients) or absence (group 2; 57 patients) of Mviab. LVEDP was higher in patients without Mviab (16 ± 8 vs 20 ± 7 mm Hg; P = .02). The multivariate analysis showed that A wall motion score index correlated with LVEDP (P = .01) independent of wall motion score index and LV end-systolic volume. Conclusions: After acute myocardial infarction, LVEDP shows wide variability and is independently associated with Mviab.
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U2 - 10.1067/mje.2002.126819
DO - 10.1067/mje.2002.126819
M3 - Article
C2 - 12464917
AN - SCOPUS:0036882353
SN - 0894-7317
VL - 15
SP - 1490
EP - 1495
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 12
ER -