Myocardial viability independently influences left ventricular diastolic function in the early phase after acute myocardial infarction

Andrea Rossi, Mariantonietta Cicoira, Maurizio Anselmi, Giorgio Golia, Loredana Latina, Monica Tinto, Piero Zardini, Jae K. Oh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: After acute myocardial infarction, a broad range of left ventricular (LV) end-diastolic pressure (LVEDP) is expected because of chamber remodeling. However, intrinsic characteristics of the infarcted tissue (necrosis or viability) may also play a role. We aimed to evaluate whether myocardial viability (Mviab) has an influence on LVEDP. Methods: One hundred twenty-three consecutive patients with acute myocardial infarction underwent low-dose dobutamine echocardiography (5-10 μg/kg/min) to assess Mviab. Mviab was quantitatively evaluated by the variation of Δ wall motion score index. Patients underwent left heart catheterization with recording of LVEDP and a complete echocardiographic examination with measurement of LV volumes, ejection fraction, and mass. Results: The overall population (81% male; mean age 58 ± 10 years) was divided into 2 groups according to the presence (group 1; 66 patients) or absence (group 2; 57 patients) of Mviab. LVEDP was higher in patients without Mviab (16 ± 8 vs 20 ± 7 mm Hg; P = .02). The multivariate analysis showed that A wall motion score index correlated with LVEDP (P = .01) independent of wall motion score index and LV end-systolic volume. Conclusions: After acute myocardial infarction, LVEDP shows wide variability and is independently associated with Mviab.

Original languageEnglish (US)
Pages (from-to)1490-1495
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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