Myocardial Perfusion

Characteristics of Distal Intramyocardial Arteriolar Trees

Mair Zamir, Andrew J. Vercnocke, Phillip K. Edwards, Jill L. Anderson, Steven M. Jorgensen, Erik L. Ritman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A combination of experimental, theoretical, and imaging methodologies is used to examine the hierarchical structure and function of intramyocardial arteriolar trees in porcine hearts to provide a window onto a region of myocardial microvasculature which has been difficult to fully explore so far. A total of 66 microvascular trees from 6 isolated myocardial specimens were analyzed, with a cumulative number of 2438 arteriolar branches greater than or equal to 40 μm lumen diameter. The distribution of flow rates within each tree was derived from an assumed power law relationship for that tree between the diameter of vessel segments and flow rates that are consistent with that power law and subject to conservation of mass along hierarchical structure of the tree. The results indicate that the power law index increases at levels of arteriolar vasculature closer to the capillary level, consistent with a concomitant decrease in shear stress acting on endothelial tissue. These results resolve a long standing predicament which could not be resolved previously because of lack of data about the 3D, interconnected, arterioles. In the context of myocardial perfusion, the results indicate that the coefficient of variation of flow rate in pre-capillary distal arterioles is high, suggesting that heterogeneity of flow rate in these arterioles is not entirely random but may be due at least in part to active control.

Original languageEnglish (US)
Pages (from-to)2771-2779
Number of pages9
JournalAnnals of Biomedical Engineering
Volume43
Issue number11
DOIs
StatePublished - May 8 2015

Fingerprint

Flow rate
Shear stress
Conservation
Tissue
Imaging techniques

Keywords

  • Cube law
  • Microvasculature
  • Murray’s law
  • Pre-capillary arterioles
  • Shear stress

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Zamir, M., Vercnocke, A. J., Edwards, P. K., Anderson, J. L., Jorgensen, S. M., & Ritman, E. L. (2015). Myocardial Perfusion: Characteristics of Distal Intramyocardial Arteriolar Trees. Annals of Biomedical Engineering, 43(11), 2771-2779. https://doi.org/10.1007/s10439-015-1325-4

Myocardial Perfusion : Characteristics of Distal Intramyocardial Arteriolar Trees. / Zamir, Mair; Vercnocke, Andrew J.; Edwards, Phillip K.; Anderson, Jill L.; Jorgensen, Steven M.; Ritman, Erik L.

In: Annals of Biomedical Engineering, Vol. 43, No. 11, 08.05.2015, p. 2771-2779.

Research output: Contribution to journalArticle

Zamir, M, Vercnocke, AJ, Edwards, PK, Anderson, JL, Jorgensen, SM & Ritman, EL 2015, 'Myocardial Perfusion: Characteristics of Distal Intramyocardial Arteriolar Trees', Annals of Biomedical Engineering, vol. 43, no. 11, pp. 2771-2779. https://doi.org/10.1007/s10439-015-1325-4
Zamir M, Vercnocke AJ, Edwards PK, Anderson JL, Jorgensen SM, Ritman EL. Myocardial Perfusion: Characteristics of Distal Intramyocardial Arteriolar Trees. Annals of Biomedical Engineering. 2015 May 8;43(11):2771-2779. https://doi.org/10.1007/s10439-015-1325-4
Zamir, Mair ; Vercnocke, Andrew J. ; Edwards, Phillip K. ; Anderson, Jill L. ; Jorgensen, Steven M. ; Ritman, Erik L. / Myocardial Perfusion : Characteristics of Distal Intramyocardial Arteriolar Trees. In: Annals of Biomedical Engineering. 2015 ; Vol. 43, No. 11. pp. 2771-2779.
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