Myocardial ischemia distal to critical coronary stenosis during cardiopulmonary bypass: fibrillating vs beating nonworking heart

Hartzell V Schaff, R. Ciardullo, J. T. Flaherty

Research output: Contribution to journalArticle


Recent experiments have demonstrated that regional myocardial ischemia develops in fibrillating hearts distal to a critical coronary stenosis (CS) during normothermic cardiopulmonary bypass. Possible mechanisms involved in the development of fibrillation induced ischemia distal to a CS are (1) higher oxygen demands compared to the beating nonworking heart, and (2) continuous high intramyocardial pressures during fibrillation which impede subendocardial blood flow. The present study was designed to test the hypothesis that converting fibrillating hearts to the beating nonworking state reduces regional myocardial ischemia distal to a critical coronary stenosis.

Original languageEnglish (US)
Pages (from-to)248-250
Number of pages3
JournalSurgical Forum
StatePublished - 1976
Externally publishedYes


ASJC Scopus subject areas

  • Surgery

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