Myocardial dysfunction associated with brain death

Clinical, echocardiographic, and pathologic features

Karl S. Dujardin, Robert B. McCully, Eelco F M Wijdicks, Henry D. Tazelaar, James B. Seward, Christopher G A McGregor, Lyle J. Olson

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Background: The sequelae of severe brain injury include myocardial dysfunction. We sought to describe the prevalence and characteristics of myocardial dysfunction seen in the context of brain-injury-related brain death and to compare these abnormalities with myocardial pathologic changes. Methods: We examined the clinical course, electrocardiograms, head computed tomography scans, and echocardiographic data of 66 consecutive patients with brain death who were evaluated as heart donors. In a sub-group of patients, we compared echocardiographic findings with pathologic findings. Results: Echocardiographic systolic myocardial dysfunction was present in 28 (42%) of 66 patients and was not predicted by clinical, electrocardiographic, or head computed tomographic scan characteristics. Ventricular arrhythmias were more common in the patients with, compared to those without, myocardial dysfunction (32% vs 0%; p < 0.001). Myocardial dysfunction was segmental in all 8 patients with spontaneous subarachnoid or intracerebral hemorrhage. In these patients, the left ventricular apex was often spared. Myocardial dysfunction was either segmental or global in 17 patients who suffered head trauma and in 3 patients who died of other central nervous system illnesses. In 11 autopsied hearts, we found poor correlation between echocardiographic dysfunction and pathologic findings. Conclusions: Systolic myocardial dysfunction is common after brain-injury-related brain death. After spontaneous subarachnoid or intracerebral hemorrhage, the pattern of dysfunction is segmental, whereas after head trauma, it may be either segmental or global. We found poor correlation between the echocardiographic distribution of dysfunction and light microscopic pathologic findings.

Original languageEnglish (US)
Pages (from-to)350-357
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume20
Issue number3
DOIs
StatePublished - 2001

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Brain Death
Brain Injuries
Cerebral Hemorrhage
Subarachnoid Hemorrhage
Craniocerebral Trauma
Head
Cardiac Arrhythmias
Electrocardiography
Central Nervous System
Tomography
Tissue Donors
Light

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Dujardin, K. S., McCully, R. B., Wijdicks, E. F. M., Tazelaar, H. D., Seward, J. B., McGregor, C. G. A., & Olson, L. J. (2001). Myocardial dysfunction associated with brain death: Clinical, echocardiographic, and pathologic features. Journal of Heart and Lung Transplantation, 20(3), 350-357. https://doi.org/10.1016/S1053-2498(00)00193-5

Myocardial dysfunction associated with brain death : Clinical, echocardiographic, and pathologic features. / Dujardin, Karl S.; McCully, Robert B.; Wijdicks, Eelco F M; Tazelaar, Henry D.; Seward, James B.; McGregor, Christopher G A; Olson, Lyle J.

In: Journal of Heart and Lung Transplantation, Vol. 20, No. 3, 2001, p. 350-357.

Research output: Contribution to journalArticle

Dujardin, KS, McCully, RB, Wijdicks, EFM, Tazelaar, HD, Seward, JB, McGregor, CGA & Olson, LJ 2001, 'Myocardial dysfunction associated with brain death: Clinical, echocardiographic, and pathologic features', Journal of Heart and Lung Transplantation, vol. 20, no. 3, pp. 350-357. https://doi.org/10.1016/S1053-2498(00)00193-5
Dujardin, Karl S. ; McCully, Robert B. ; Wijdicks, Eelco F M ; Tazelaar, Henry D. ; Seward, James B. ; McGregor, Christopher G A ; Olson, Lyle J. / Myocardial dysfunction associated with brain death : Clinical, echocardiographic, and pathologic features. In: Journal of Heart and Lung Transplantation. 2001 ; Vol. 20, No. 3. pp. 350-357.
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AU - McGregor, Christopher G A

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