Myocardial degradation and left bundle branch block predict conversion to low ejection fraction in heart failure with preserved systolic function

George O. Angheloiu, Mouyyad Rahaby, Randall C. Starling, Viorel Angheloiu, Dennis M. McNamara, Mohamad H. Yamani, James B. Young

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The authors prospectively investigated whether left bundle branch block (LBBB) and myocardial degradation as indicated by elevated troponin T (tnT) predict the phenomenon of systolic conversion to low ejection fraction (EF .40%) in patients with nonsignificant coronary disease and heart failure with preserved systolic function (HFPSF) (initial EF > 40%). Thirty consecutive patients with HFPSF were included and followed over a 4-year interval. A follow-up EF assessment was performed in 25 patients. Six of 15 patients with tnT .0.01 ng/mL demonstrated systolic conversion to low EF on follow-up, while none of the 10 patients with tnT < 0.01 ng/mL experienced this phenomenon (P=.03). Five of the 6 converters presented with LBBB, while only 1 of the 19 nonconverters had this abnormality (P=.0007). Four of the 6 converters had an initial EF > 50%. Myocardial degradation and LBBB predicted systolic conversion in HFPSF patients with nonsignificant coronary disease. Congest Heart Fail. 2008;14:192.196. c2008 Le Jacq.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalCongestive Heart Failure
Volume14
Issue number4
DOIs
StatePublished - 2008

Fingerprint

Bundle-Branch Block
Heart Failure
Troponin T
Coronary Disease
Conjugated (USP) Estrogens

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

Myocardial degradation and left bundle branch block predict conversion to low ejection fraction in heart failure with preserved systolic function. / Angheloiu, George O.; Rahaby, Mouyyad; Starling, Randall C.; Angheloiu, Viorel; McNamara, Dennis M.; Yamani, Mohamad H.; Young, James B.

In: Congestive Heart Failure, Vol. 14, No. 4, 2008, p. 192-196.

Research output: Contribution to journalArticle

Angheloiu, George O. ; Rahaby, Mouyyad ; Starling, Randall C. ; Angheloiu, Viorel ; McNamara, Dennis M. ; Yamani, Mohamad H. ; Young, James B. / Myocardial degradation and left bundle branch block predict conversion to low ejection fraction in heart failure with preserved systolic function. In: Congestive Heart Failure. 2008 ; Vol. 14, No. 4. pp. 192-196.
@article{3df2ca39b7bd445491cbe48f751d38b1,
title = "Myocardial degradation and left bundle branch block predict conversion to low ejection fraction in heart failure with preserved systolic function",
abstract = "The authors prospectively investigated whether left bundle branch block (LBBB) and myocardial degradation as indicated by elevated troponin T (tnT) predict the phenomenon of systolic conversion to low ejection fraction (EF .40{\%}) in patients with nonsignificant coronary disease and heart failure with preserved systolic function (HFPSF) (initial EF > 40{\%}). Thirty consecutive patients with HFPSF were included and followed over a 4-year interval. A follow-up EF assessment was performed in 25 patients. Six of 15 patients with tnT .0.01 ng/mL demonstrated systolic conversion to low EF on follow-up, while none of the 10 patients with tnT < 0.01 ng/mL experienced this phenomenon (P=.03). Five of the 6 converters presented with LBBB, while only 1 of the 19 nonconverters had this abnormality (P=.0007). Four of the 6 converters had an initial EF > 50{\%}. Myocardial degradation and LBBB predicted systolic conversion in HFPSF patients with nonsignificant coronary disease. Congest Heart Fail. 2008;14:192.196. c2008 Le Jacq.",
author = "Angheloiu, {George O.} and Mouyyad Rahaby and Starling, {Randall C.} and Viorel Angheloiu and McNamara, {Dennis M.} and Yamani, {Mohamad H.} and Young, {James B.}",
year = "2008",
doi = "10.1111/j.1751-7133.2008.07827.x",
language = "English (US)",
volume = "14",
pages = "192--196",
journal = "Prevention and Management of Congestive Heart Failure",
issn = "1079-7998",
publisher = "Le Jacq Communications, Inc.",
number = "4",

}

TY - JOUR

T1 - Myocardial degradation and left bundle branch block predict conversion to low ejection fraction in heart failure with preserved systolic function

AU - Angheloiu, George O.

AU - Rahaby, Mouyyad

AU - Starling, Randall C.

AU - Angheloiu, Viorel

AU - McNamara, Dennis M.

AU - Yamani, Mohamad H.

AU - Young, James B.

PY - 2008

Y1 - 2008

N2 - The authors prospectively investigated whether left bundle branch block (LBBB) and myocardial degradation as indicated by elevated troponin T (tnT) predict the phenomenon of systolic conversion to low ejection fraction (EF .40%) in patients with nonsignificant coronary disease and heart failure with preserved systolic function (HFPSF) (initial EF > 40%). Thirty consecutive patients with HFPSF were included and followed over a 4-year interval. A follow-up EF assessment was performed in 25 patients. Six of 15 patients with tnT .0.01 ng/mL demonstrated systolic conversion to low EF on follow-up, while none of the 10 patients with tnT < 0.01 ng/mL experienced this phenomenon (P=.03). Five of the 6 converters presented with LBBB, while only 1 of the 19 nonconverters had this abnormality (P=.0007). Four of the 6 converters had an initial EF > 50%. Myocardial degradation and LBBB predicted systolic conversion in HFPSF patients with nonsignificant coronary disease. Congest Heart Fail. 2008;14:192.196. c2008 Le Jacq.

AB - The authors prospectively investigated whether left bundle branch block (LBBB) and myocardial degradation as indicated by elevated troponin T (tnT) predict the phenomenon of systolic conversion to low ejection fraction (EF .40%) in patients with nonsignificant coronary disease and heart failure with preserved systolic function (HFPSF) (initial EF > 40%). Thirty consecutive patients with HFPSF were included and followed over a 4-year interval. A follow-up EF assessment was performed in 25 patients. Six of 15 patients with tnT .0.01 ng/mL demonstrated systolic conversion to low EF on follow-up, while none of the 10 patients with tnT < 0.01 ng/mL experienced this phenomenon (P=.03). Five of the 6 converters presented with LBBB, while only 1 of the 19 nonconverters had this abnormality (P=.0007). Four of the 6 converters had an initial EF > 50%. Myocardial degradation and LBBB predicted systolic conversion in HFPSF patients with nonsignificant coronary disease. Congest Heart Fail. 2008;14:192.196. c2008 Le Jacq.

UR - http://www.scopus.com/inward/record.url?scp=55249099073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55249099073&partnerID=8YFLogxK

U2 - 10.1111/j.1751-7133.2008.07827.x

DO - 10.1111/j.1751-7133.2008.07827.x

M3 - Article

C2 - 18772624

AN - SCOPUS:55249099073

VL - 14

SP - 192

EP - 196

JO - Prevention and Management of Congestive Heart Failure

JF - Prevention and Management of Congestive Heart Failure

SN - 1079-7998

IS - 4

ER -