Myocardial contrast echocardiography in biopsy-proven primary cardiac amyloidosis

Sahar S. Abdelmoneim, Mathieu Bernier, Diego Bellavia, Imran S. Syed, Sunil V. Mankad, Krishnaswamy Chandrasekaran, Patricia Pellikka, Sharon L. Mulvagh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cardiac vasculature is affected in 88-90% of patients with primary cardiac amyloidosis (CA). Myocardial contrast echocardiography (MCE) relies on the ultrasound detection of microbubble contrast agents that are solely confined to the intravascular space, and are therefore useful in the evaluation of flow in the microvasculature. This is the first case report describing the use of MCE during vasodilator stress to evaluate coronary flow reserve in a patient with biopsy-proven primary CA and angiographically normal coronaries. Qualitative MCE demonstrated delayed replenishment of microbubbles during peak stress; quantitative analysis was consistent with a reduction in total myocardial blood flow and reserve values. Comparative imaging modalities including strain and strain rate imaging, magnetic resonance imaging, and myocardial scintigraphy were suggestive to the diagnosis of CA. In conclusion, MCE is a method for recognition of microvascular dysfunction, and might be considered as a useful tool to augment echocardiographic assessment in the early diagnosis of CA.

Original languageEnglish (US)
Pages (from-to)338-341
Number of pages4
JournalEuropean Journal of Echocardiography
Volume9
Issue number2
DOIs
StatePublished - Mar 2008

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Echocardiography
Biopsy
Microbubbles
Amyloidosis
Myocardial Perfusion Imaging
Microvessels
Vasodilator Agents
Contrast Media
Early Diagnosis
Magnetic Resonance Imaging
Primary amyloidosis

Keywords

  • Amyloidosis
  • Contrast
  • Echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Abdelmoneim, S. S., Bernier, M., Bellavia, D., Syed, I. S., Mankad, S. V., Chandrasekaran, K., ... Mulvagh, S. L. (2008). Myocardial contrast echocardiography in biopsy-proven primary cardiac amyloidosis. European Journal of Echocardiography, 9(2), 338-341. https://doi.org/10.1093/ejechocard/jen017

Myocardial contrast echocardiography in biopsy-proven primary cardiac amyloidosis. / Abdelmoneim, Sahar S.; Bernier, Mathieu; Bellavia, Diego; Syed, Imran S.; Mankad, Sunil V.; Chandrasekaran, Krishnaswamy; Pellikka, Patricia; Mulvagh, Sharon L.

In: European Journal of Echocardiography, Vol. 9, No. 2, 03.2008, p. 338-341.

Research output: Contribution to journalArticle

Abdelmoneim, SS, Bernier, M, Bellavia, D, Syed, IS, Mankad, SV, Chandrasekaran, K, Pellikka, P & Mulvagh, SL 2008, 'Myocardial contrast echocardiography in biopsy-proven primary cardiac amyloidosis', European Journal of Echocardiography, vol. 9, no. 2, pp. 338-341. https://doi.org/10.1093/ejechocard/jen017
Abdelmoneim SS, Bernier M, Bellavia D, Syed IS, Mankad SV, Chandrasekaran K et al. Myocardial contrast echocardiography in biopsy-proven primary cardiac amyloidosis. European Journal of Echocardiography. 2008 Mar;9(2):338-341. https://doi.org/10.1093/ejechocard/jen017
Abdelmoneim, Sahar S. ; Bernier, Mathieu ; Bellavia, Diego ; Syed, Imran S. ; Mankad, Sunil V. ; Chandrasekaran, Krishnaswamy ; Pellikka, Patricia ; Mulvagh, Sharon L. / Myocardial contrast echocardiography in biopsy-proven primary cardiac amyloidosis. In: European Journal of Echocardiography. 2008 ; Vol. 9, No. 2. pp. 338-341.
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