Myocardial cobalt levels are elevated in the setting of total hip arthroplasty

Cody C. Wyles, T. Carson Wright, Melanie C. Bois, Shahrier Amin, Ahmed Fayyaz, Sarah M. Jenkins, Saranya P. Wyles, Patrick L. Day, David L. Murray, Robert T. Trousdale, Nandan S. Anavekar, William D. Edwards, Joseph Maleszewski

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Arthroplasty implants commonly contain elemental metal that may undergo wear-related release. Recently, cases of hip implant-associated myocardial injury have been reported. However, we are not aware of any previous study that has systematically measured myocardial metal levels or examined the relationship with total hip arthroplasty (THA). Methods: Archives of our institution were queried for autopsies of individuals who had undergone THA between 1990 and 2013. Myocardial tissue samples were analyzed for cobalt (Co) and chromium (Cr) levels with inductively coupled plasma mass spectroscopy. Seventy-five Co/Cr-on-polyethylene THA cases were included (mean age at time of death = 77.4 years; 49% women) as were 73 non-arthroplasty controls matched for age, sex, and history of hypertension and diabetes mellitus. Results: Significantly higher median myocardial concentrations of Co were observed in individuals with THA compared with controls (0.12 versus 0.06 mg/g, p < 0.0001). The median Co concentration was 69% higher in patients who had undergone THA revision (0.169 mg/g) than in those who underwent primary THA (0.100 mg/g; p = 0.004). In general, higher Co levels were observed in those with multiple replaced joints, although this finding only trended toward significance. Cardiomegaly, interstitial fibrosis, and decreased ejection fraction were observed more frequently in the postmortem samples of patients with implants than in those of controls (p = 0.0002, 0.044, and 0.0039, respectively). Conclusions: We believe this to be the first study to quantify metal levels in cardiac tissue in patients with and without joint replacement. The elevated Co levels, in concert with cardiomegaly and increased interstitial fibrosis found during autopsy, in the arthroplasty cohort are novel, important findings. Although Co levels were significantly elevated above those in controls, the majority were below those seen in clinical case reports of death from Co cardiotoxicity associated with metal-on-metal prostheses. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

Original languageEnglish (US)
Pages (from-to)e118
JournalJournal of Bone and Joint Surgery - American Volume
Volume99
Issue number22
DOIs
StatePublished - Jan 1 2017

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Cobalt
Arthroplasty
Hip
Metals
Cardiomegaly
Chromium
Autopsy
Replacement Arthroplasties
Fibrosis
Polyethylene
Prostheses and Implants
Mass Spectrometry
Diabetes Mellitus
Joints
Hypertension
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Myocardial cobalt levels are elevated in the setting of total hip arthroplasty. / Wyles, Cody C.; Carson Wright, T.; Bois, Melanie C.; Amin, Shahrier; Fayyaz, Ahmed; Jenkins, Sarah M.; Wyles, Saranya P.; Day, Patrick L.; Murray, David L.; Trousdale, Robert T.; Anavekar, Nandan S.; Edwards, William D.; Maleszewski, Joseph.

In: Journal of Bone and Joint Surgery - American Volume, Vol. 99, No. 22, 01.01.2017, p. e118.

Research output: Contribution to journalArticle

Wyles, CC, Carson Wright, T, Bois, MC, Amin, S, Fayyaz, A, Jenkins, SM, Wyles, SP, Day, PL, Murray, DL, Trousdale, RT, Anavekar, NS, Edwards, WD & Maleszewski, J 2017, 'Myocardial cobalt levels are elevated in the setting of total hip arthroplasty', Journal of Bone and Joint Surgery - American Volume, vol. 99, no. 22, pp. e118. https://doi.org/10.2106/JBJS.17.00159
Wyles, Cody C. ; Carson Wright, T. ; Bois, Melanie C. ; Amin, Shahrier ; Fayyaz, Ahmed ; Jenkins, Sarah M. ; Wyles, Saranya P. ; Day, Patrick L. ; Murray, David L. ; Trousdale, Robert T. ; Anavekar, Nandan S. ; Edwards, William D. ; Maleszewski, Joseph. / Myocardial cobalt levels are elevated in the setting of total hip arthroplasty. In: Journal of Bone and Joint Surgery - American Volume. 2017 ; Vol. 99, No. 22. pp. e118.
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abstract = "Background: Arthroplasty implants commonly contain elemental metal that may undergo wear-related release. Recently, cases of hip implant-associated myocardial injury have been reported. However, we are not aware of any previous study that has systematically measured myocardial metal levels or examined the relationship with total hip arthroplasty (THA). Methods: Archives of our institution were queried for autopsies of individuals who had undergone THA between 1990 and 2013. Myocardial tissue samples were analyzed for cobalt (Co) and chromium (Cr) levels with inductively coupled plasma mass spectroscopy. Seventy-five Co/Cr-on-polyethylene THA cases were included (mean age at time of death = 77.4 years; 49{\%} women) as were 73 non-arthroplasty controls matched for age, sex, and history of hypertension and diabetes mellitus. Results: Significantly higher median myocardial concentrations of Co were observed in individuals with THA compared with controls (0.12 versus 0.06 mg/g, p < 0.0001). The median Co concentration was 69{\%} higher in patients who had undergone THA revision (0.169 mg/g) than in those who underwent primary THA (0.100 mg/g; p = 0.004). In general, higher Co levels were observed in those with multiple replaced joints, although this finding only trended toward significance. Cardiomegaly, interstitial fibrosis, and decreased ejection fraction were observed more frequently in the postmortem samples of patients with implants than in those of controls (p = 0.0002, 0.044, and 0.0039, respectively). Conclusions: We believe this to be the first study to quantify metal levels in cardiac tissue in patients with and without joint replacement. The elevated Co levels, in concert with cardiomegaly and increased interstitial fibrosis found during autopsy, in the arthroplasty cohort are novel, important findings. Although Co levels were significantly elevated above those in controls, the majority were below those seen in clinical case reports of death from Co cardiotoxicity associated with metal-on-metal prostheses. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.",
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AU - Carson Wright, T.

AU - Bois, Melanie C.

AU - Amin, Shahrier

AU - Fayyaz, Ahmed

AU - Jenkins, Sarah M.

AU - Wyles, Saranya P.

AU - Day, Patrick L.

AU - Murray, David L.

AU - Trousdale, Robert T.

AU - Anavekar, Nandan S.

AU - Edwards, William D.

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N2 - Background: Arthroplasty implants commonly contain elemental metal that may undergo wear-related release. Recently, cases of hip implant-associated myocardial injury have been reported. However, we are not aware of any previous study that has systematically measured myocardial metal levels or examined the relationship with total hip arthroplasty (THA). Methods: Archives of our institution were queried for autopsies of individuals who had undergone THA between 1990 and 2013. Myocardial tissue samples were analyzed for cobalt (Co) and chromium (Cr) levels with inductively coupled plasma mass spectroscopy. Seventy-five Co/Cr-on-polyethylene THA cases were included (mean age at time of death = 77.4 years; 49% women) as were 73 non-arthroplasty controls matched for age, sex, and history of hypertension and diabetes mellitus. Results: Significantly higher median myocardial concentrations of Co were observed in individuals with THA compared with controls (0.12 versus 0.06 mg/g, p < 0.0001). The median Co concentration was 69% higher in patients who had undergone THA revision (0.169 mg/g) than in those who underwent primary THA (0.100 mg/g; p = 0.004). In general, higher Co levels were observed in those with multiple replaced joints, although this finding only trended toward significance. Cardiomegaly, interstitial fibrosis, and decreased ejection fraction were observed more frequently in the postmortem samples of patients with implants than in those of controls (p = 0.0002, 0.044, and 0.0039, respectively). Conclusions: We believe this to be the first study to quantify metal levels in cardiac tissue in patients with and without joint replacement. The elevated Co levels, in concert with cardiomegaly and increased interstitial fibrosis found during autopsy, in the arthroplasty cohort are novel, important findings. Although Co levels were significantly elevated above those in controls, the majority were below those seen in clinical case reports of death from Co cardiotoxicity associated with metal-on-metal prostheses. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

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