Myocardial bridging in adult patients with hypertrophic cardiomyopathy

Paul Sorajja, Steve R. Ommen, Rick A. Nishimura, Bernard J. Gersh, A. Jamil Tajik, David R. Holmes

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

OBJECTIVES: This investigation examined the risk of sudden cardiac death and other mortality in adult patients with hypertrophic cardiomyopathy (HCM) who have myocardial bridging diagnosed at coronary angiography. BACKGROUND: Several reports have associated myocardial bridging with an adverse prognosis in pediatric HCM patients, but the prognosis of myocardial bridging in adult patients with HCM is unknown. METHODS: The coronary angiograms of 425 patients with HCM (mean age 60 ± 15 years [range 18 to 89 years]) at the Mayo Clinic were examined for the presence of myocardial bridging. Clinical follow-up was conducted to assess mortality. Survival of patients with bridging was compared with HCM patients who also underwent angiography but who did not have evidence of bridging. RESULTS: A total of 64 patients (15%) had myocardial bridging. The mean follow-up for the entire study was 6.8 ± 5.4 years. There was no difference in survival free of all-cause mortality (5-year estimate, bridging vs. no bridging, 91% vs. 85%; p = 0.42), all cardiac death (93% vs. 89%; p = 0.60), and sudden cardiac death (95% vs. 97%; p = 0.72). Univariate and multivariate proportional hazards models also did not identify the presence of bridging or specific characteristics of the degree or extent of bridging with a poor outcome. CONCLUSIONS: This study observed no increased risk of death, including sudden cardiac death, among adult patients with HCM who had myocardial bridging diagnosed at coronary angiography.

Original languageEnglish (US)
Pages (from-to)889-894
Number of pages6
JournalJournal of the American College of Cardiology
Volume42
Issue number5
DOIs
StatePublished - Sep 3 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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