Myocardial blood flow in patients with dilated cardiomyopathy: Quantitative assessment with velocity-encoded cine magnetic resonance imaging of the coronary sinus

Norbert Watzinger, Gunnar K. Lund, Maythem Saeed, Gautham P. Reddy, Philip A. Araoz, Ming Yang, Alan B. Schwartz, Martin Bedigian, Charles B. Higgins

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Purpose: To quantify global myocardial perfusion using magnetic resonance imaging (MRI) In patients with heart failure due to idiopathic dilated cardiomyopathy (IDC) and to compare myocardial perfusion and microvascular reactivity with healthy subjects. Materials and Methods: A total of 19 subjects (healthy volunteers (N = 12) and IDC patients (N = 7)) were studied using cine MRI to measure left ventricular (LV) mass and a velocity-encoded cine MRI technique to measure coronary sinus flow at rest and after dipyridamole-induced hyperemia. Absolute values of total myocardial blood flow (MBF) were calculated from coronary sinus flow and LV mass. Results: At baseline, MBF was not significantly different in patients with IDC (0.48 ± 0.07 mL/minute/g) and healthy subjects (0.55 ± 0.19 mL/minute/g, P = 0.41). After dipyridamole administration, MBF in IDC patients increased to a level significantly less than that in normal volunteers (1.05 ± 0.35 mL/minute/g vs. 1.99 ± 1.05 mL/minute/g, P < 0.05). Consequently, MBF reserve was impaired in patients with IDC (2.19 ± 0.77) compared to that In healthy subjects (3.51 ± 1.29, P < 0.05). A moderate correlation was found between MBF reserve and LV ejection fraction (r = 0.48, P< 0.05). Conclusion: MBF reserve is reduced in patients with IDC, indicating that coronary microcirculatory flow is impaired. This integrated MRI approach allows quantitative measurement of global MBF in humans and may have the potential to study the effects of pharmacological interventions on myocardial perfusion.

Original languageEnglish (US)
Pages (from-to)347-353
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Volume21
Issue number4
DOIs
StatePublished - Apr 2005

Keywords

  • Coronary microcirculation
  • Coronary sinus flow
  • Idiopathlc dilated cardiomyopathy
  • MRI
  • Myocardial perfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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