Abstract
The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.
Original language | English (US) |
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Pages (from-to) | 528-535 |
Number of pages | 8 |
Journal | Journal of cardiovascular translational research |
Volume | 8 |
Issue number | 9 |
DOIs | |
State | Published - Dec 1 2015 |
Keywords
- Acute coronary syndrome
- Biomarker
- Ischemia
- Myocardium
- Pregnancy-associated plasma protein-A
- Reperfusion
ASJC Scopus subject areas
- Molecular Medicine
- Genetics
- Pharmaceutical Science
- Cardiology and Cardiovascular Medicine
- Genetics(clinical)