Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Lasse Bach Steffensen, Christian Bo Poulsen, Jeong Shim, Marie Bek, Kevin Jacobsen, Cheryl A Conover, Jacob Fog Bentzon, Claus Oxvig

Research output: Contribution to journalArticle

Abstract

The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

Original languageEnglish (US)
Pages (from-to)528-535
Number of pages8
JournalJournal of Cardiovascular Translational Research
Volume8
Issue number9
DOIs
StatePublished - Dec 1 2015

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Keywords

  • Acute coronary syndrome
  • Biomarker
  • Ischemia
  • Myocardium
  • Pregnancy-associated plasma protein-A
  • Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

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