Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

Lasse Bach Steffensen, Christian Bo Poulsen, Jeong Shim, Marie Bek, Kevin Jacobsen, Cheryl A Conover, Jacob Fog Bentzon, Claus Oxvig

Research output: Contribution to journalArticle

Abstract

The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

Original languageEnglish (US)
Pages (from-to)528-535
Number of pages8
JournalJournal of Cardiovascular Translational Research
Volume8
Issue number9
DOIs
StatePublished - Dec 1 2015

Fingerprint

Pregnancy-Associated Plasma Protein-A
Myocardial Ischemia
Swine
Acute Coronary Syndrome
Ligation
Biomarkers
Femoral Artery
Heparin
Atherosclerosis
Coronary Vessels
Myocardium
Ischemia
Extremities

Keywords

  • Acute coronary syndrome
  • Biomarker
  • Ischemia
  • Myocardium
  • Pregnancy-associated plasma protein-A
  • Reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs. / Steffensen, Lasse Bach; Poulsen, Christian Bo; Shim, Jeong; Bek, Marie; Jacobsen, Kevin; Conover, Cheryl A; Bentzon, Jacob Fog; Oxvig, Claus.

In: Journal of Cardiovascular Translational Research, Vol. 8, No. 9, 01.12.2015, p. 528-535.

Research output: Contribution to journalArticle

Steffensen, Lasse Bach ; Poulsen, Christian Bo ; Shim, Jeong ; Bek, Marie ; Jacobsen, Kevin ; Conover, Cheryl A ; Bentzon, Jacob Fog ; Oxvig, Claus. / Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs. In: Journal of Cardiovascular Translational Research. 2015 ; Vol. 8, No. 9. pp. 528-535.
@article{f28d755006fc464292aad4dbc35fe88e,
title = "Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs",
abstract = "The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.",
keywords = "Acute coronary syndrome, Biomarker, Ischemia, Myocardium, Pregnancy-associated plasma protein-A, Reperfusion",
author = "Steffensen, {Lasse Bach} and Poulsen, {Christian Bo} and Jeong Shim and Marie Bek and Kevin Jacobsen and Conover, {Cheryl A} and Bentzon, {Jacob Fog} and Claus Oxvig",
year = "2015",
month = "12",
day = "1",
doi = "10.1007/s12265-015-9656-y",
language = "English (US)",
volume = "8",
pages = "528--535",
journal = "Journal of Cardiovascular Translational Research",
issn = "1937-5387",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - Myocardial and Peripheral Ischemia Causes an Increase in Circulating Pregnancy-Associated Plasma Protein-A in Non-atherosclerotic, Non-heparinized Pigs

AU - Steffensen, Lasse Bach

AU - Poulsen, Christian Bo

AU - Shim, Jeong

AU - Bek, Marie

AU - Jacobsen, Kevin

AU - Conover, Cheryl A

AU - Bentzon, Jacob Fog

AU - Oxvig, Claus

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

AB - The usefulness of circulating pregnancy-associated plasma protein-A (PAPP-A) as a biomarker for acute coronary syndrome (ACS) is widely debated. We used the pig as a model to assess PAPP-A dynamics in the setting of myocardial ischemia. Induction of myocardial ischemia by ligation of the left anterior descending (LAD) coronary artery caused a systemic rise in PAPP-A. However, the ischemic myocardium was excluded as the source of PAPP-A. Interestingly, induction of ischemia in peripheral tissues by ligation of the left femoral artery caused a systemic rise in PAPP-A originating from the left hind limb. This is the first study to demonstrate PAPP-A elevations in the absence of atherosclerosis or heparin during myocardial ischemia. Our findings thus add to the current discussion of the usefulness of PAPP-A as a biomarker for ACS.

KW - Acute coronary syndrome

KW - Biomarker

KW - Ischemia

KW - Myocardium

KW - Pregnancy-associated plasma protein-A

KW - Reperfusion

UR - http://www.scopus.com/inward/record.url?scp=84949086940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949086940&partnerID=8YFLogxK

U2 - 10.1007/s12265-015-9656-y

DO - 10.1007/s12265-015-9656-y

M3 - Article

C2 - 26443031

AN - SCOPUS:84949086940

VL - 8

SP - 528

EP - 535

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

SN - 1937-5387

IS - 9

ER -