Myeloproliferative Neoplasms: Translating New Discoveries Into Better Outcomes, Better Quality of Life

Leslie Padrnos, Ruben A. Mesa

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Despite the identification of JAK mutations and the development of targeted inhibitors, there remain significant unmet needs for patients with myeloproliferative neoplasms. Identification of the myeloproliferative neoplasm populations not currently benefiting from JAK inhibitor therapy highlights the therapeutic deficits still present in this heterogeneous stem cell malignancy. While JAK inhibition has provided significant benefits for patients with intermediate-2 or high-risk myelofibrosis and in patients with polycythemia vera in the second-line setting, JAK inhibitor monotherapy is not approved and not appropriate for all patients with myeloproliferative neoplasms. Continued investigation into additional JAK inhibitors, combination therapy, and novel pathway therapeutics remains key to improving outcomes for all patients with myeloproliferative neoplasms. While therapeutic advances in the JAK inhibitor arena or involving alternative pathways are crucial to improving outcomes in myeloproliferative neoplasms, it is also important to reconsider the role of constitutional symptoms in affected patients as an indication for treatment with agents, such as JAK inhibitors, that can mitigate these debilitating symptoms. In this review, we demonstrate the evolving landscape of clinical investigations that address the important therapeutic needs of patients with myeloproliferative neoplasms.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalOncology (Williston Park, N.Y.)
Volume31
Issue number7
StatePublished - Jul 15 2017

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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