Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis

Raoul Tibes, Gurcharan Singh Khera, Ruben A. Mesa

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The myeloproliferative neoplasms are a group of clonal hematological (stem cell) disorders with terminal myeloid cell expansion in the peripheral blood. Originally described by William Dameshek in 1951 based on clinical and bone marrow similarities, in 2001 myeloproliferative neoplasms were classified by the World Health Organization Classification which was updated in 2008. Myeloproliferative neoplasms are classified into five major entities (acute myeloid and lymphoid leukemias are separate entities). Myeloproliferative neoplasms can be divided into "classic" forms, which are chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis, and "atypical" forms, consisting of chronic neutrophilic leukemia, chronic eosinophilic leukemia not otherwise specified, mastocytosis and myeloproliferative neoplasm unclassifiable. The four "classic" myeloproliferative neoplasms will be discussed in this chapter, given their rarity.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer
PublisherJohn Wiley and Sons
Pages647-658
Number of pages12
ISBN (Print)9781118083734
DOIs
StatePublished - Sep 20 2012

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Keywords

  • CEL
  • CML
  • CNL
  • Essential thrombocythemia
  • MPNs
  • Polycythemia vera
  • Primary myelofibrosis
  • SM

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tibes, R., Khera, G. S., & Mesa, R. A. (2012). Myeloproliferative Neoplasms: Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis. In Textbook of Uncommon Cancer (pp. 647-658). John Wiley and Sons. https://doi.org/10.1002/9781118464557.ch47