Myeloperoxidase G-463A polymorphism and lung cancer: A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis

Emanuela Taioli, Simone Benhamou, Christine Bouchardy, Ingolf Cascorbi, Nohelia Cajas-Salazar, Heike Dally, Kwun M. Fong, Jill E. Larsen, Loic Le Marchand, Stephanie J. London, Angela Risch, Margaret R. Spitz, Isabelle Stucker, Brian Weinshenker, Xifeng Wu, Ping Yang

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Myeloperoxidase is a phase I metabolic enzyme that converts the metabolites of benzo[a]pyrene from tobacco smoke into highly reactive epoxides. A polymorphism in the promoter region of myeloperoxidase (463G→A) has been found to be inversely associated with lung cancer; differences in the association with age and gender have been suggested. We conducted a pooled analysis of individual data from 10 studies (3688 cases and 3874 controls) from the Genetic Susceptibility to Environmental Carcinogens database. The odds ratio for lung cancer was 0.88 (95% confidence interval: 0.80-0.97) for the AG variant of myeloperoxidase G-463A polymorphism, and 0.71 (95% confidence interval: 0.57-0.88) for the AA variant after adjusting for smoking, age, gender, and ethnicity. The inverse association between lung cancer and myeloperoxidase G-463A polymorphism was equally found in males and females (odds ratio for the AA genotype 0.73 [95% confidence interval: 0.56-0.96] and 0.67 [95% confidence interval: 0.46-0.98], respectively), without differences in the association according to age in the two genders. The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalGenetics in Medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 2007

Keywords

  • Cooperative studies
  • Epidemiology
  • Metabolic gene polymorphisms
  • Smoking

ASJC Scopus subject areas

  • Genetics(clinical)

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    Taioli, E., Benhamou, S., Bouchardy, C., Cascorbi, I., Cajas-Salazar, N., Dally, H., Fong, K. M., Larsen, J. E., Le Marchand, L., London, S. J., Risch, A., Spitz, M. R., Stucker, I., Weinshenker, B., Wu, X., & Yang, P. (2007). Myeloperoxidase G-463A polymorphism and lung cancer: A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis. Genetics in Medicine, 9(2), 67-73. https://doi.org/10.1097/GIM.0b013e31803068b1