Myeloperoxidase G-463A polymorphism and lung cancer

A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis

Emanuela Taioli, Simone Benhamou, Christine Bouchardy, Ingolf Cascorbi, Nohelia Cajas-Salazar, Heike Dally, Kwun M. Fong, Jill E. Larsen, Loic Le Marchand, Stephanie J. London, Angela Risch, Margaret R. Spitz, Isabelle Stucker, Brian G Weinshenker, Xifeng Wu, Ping Yang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Myeloperoxidase is a phase I metabolic enzyme that converts the metabolites of benzo[a]pyrene from tobacco smoke into highly reactive epoxides. A polymorphism in the promoter region of myeloperoxidase (463G→A) has been found to be inversely associated with lung cancer; differences in the association with age and gender have been suggested. We conducted a pooled analysis of individual data from 10 studies (3688 cases and 3874 controls) from the Genetic Susceptibility to Environmental Carcinogens database. The odds ratio for lung cancer was 0.88 (95% confidence interval: 0.80-0.97) for the AG variant of myeloperoxidase G-463A polymorphism, and 0.71 (95% confidence interval: 0.57-0.88) for the AA variant after adjusting for smoking, age, gender, and ethnicity. The inverse association between lung cancer and myeloperoxidase G-463A polymorphism was equally found in males and females (odds ratio for the AA genotype 0.73 [95% confidence interval: 0.56-0.96] and 0.67 [95% confidence interval: 0.46-0.98], respectively), without differences in the association according to age in the two genders. The myeloperoxidase G-463A polymorphism was significantly protective in "ever" smokers but not in "never" smokers. Myeloperoxidase is a key enzyme in tobacco-induced carcinogenesis.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalGenetics in Medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 2007

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Environmental Carcinogens
Genetic Predisposition to Disease
Peroxidase
Lung Neoplasms
Confidence Intervals
Tobacco
Odds Ratio
Benzo(a)pyrene
Epoxy Compounds
Enzymes
Genetic Promoter Regions
Smoke
Carcinogenesis
Smoking
Genotype
Databases

Keywords

  • Cooperative studies
  • Epidemiology
  • Metabolic gene polymorphisms
  • Smoking

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Myeloperoxidase G-463A polymorphism and lung cancer : A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis. / Taioli, Emanuela; Benhamou, Simone; Bouchardy, Christine; Cascorbi, Ingolf; Cajas-Salazar, Nohelia; Dally, Heike; Fong, Kwun M.; Larsen, Jill E.; Le Marchand, Loic; London, Stephanie J.; Risch, Angela; Spitz, Margaret R.; Stucker, Isabelle; Weinshenker, Brian G; Wu, Xifeng; Yang, Ping.

In: Genetics in Medicine, Vol. 9, No. 2, 02.2007, p. 67-73.

Research output: Contribution to journalArticle

Taioli, E, Benhamou, S, Bouchardy, C, Cascorbi, I, Cajas-Salazar, N, Dally, H, Fong, KM, Larsen, JE, Le Marchand, L, London, SJ, Risch, A, Spitz, MR, Stucker, I, Weinshenker, BG, Wu, X & Yang, P 2007, 'Myeloperoxidase G-463A polymorphism and lung cancer: A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis', Genetics in Medicine, vol. 9, no. 2, pp. 67-73. https://doi.org/10.1097/GIM.0b013e31803068b1
Taioli, Emanuela ; Benhamou, Simone ; Bouchardy, Christine ; Cascorbi, Ingolf ; Cajas-Salazar, Nohelia ; Dally, Heike ; Fong, Kwun M. ; Larsen, Jill E. ; Le Marchand, Loic ; London, Stephanie J. ; Risch, Angela ; Spitz, Margaret R. ; Stucker, Isabelle ; Weinshenker, Brian G ; Wu, Xifeng ; Yang, Ping. / Myeloperoxidase G-463A polymorphism and lung cancer : A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis. In: Genetics in Medicine. 2007 ; Vol. 9, No. 2. pp. 67-73.
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