Myeloid growth factors

Jeffrey Crawford, James Armitage, Lodovico Balducci, Charles Bennett, Douglas W. Blayney, Spero R. Cataland, David C. Dale, George D. Demetri, Harry P. Erba, James Foran, Alison G. Freifeld, Marti Goemann, Mark L. Heaney, Sally Htoy, Susan Hudock, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Laura Boehnke Michaud, Sarah C. MiyataMartin S. Tallman, Saroj Vadhan-Raj, Peter Westervelt, Michael K. Wong

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Neutropenia and resulting febrile neutropenia (FN) can be induced by myelosuppressive chemotherapy. FN is a major dose-limiting toxicity of chemotherapy, often requiring hospitalization to evaluate and treat. Further, these complications often result in dose reductions or treatment delays, which may compromise clinical outcomes. Although the prophylactic use of colony-stimulating factors (CSFs) can reduce the risk, severity, and duration of FN, they are not administered to all patients undergoing myelosuppressive chemotherapy because of the associated costs. Selective use, however, may enhance cost-effectiveness by directing treatment toward patients most likely to benefit. Filgrastim and pegfilgrastim, both granulocyte colony-stimulating factors (G-CSF), have FDA approval for use in the prevention of chemotherapy-induced neutropenia. In contrast, the labeled indication for sargramostim, a granulocyte-macrophage colony-stimulating factor (GM-CSF), is limited to use after induction therapy for acute myeloid leukemia and in various stem cell transplantation settings. These guidelines focus on the use of CSFs in the cancer setting; specifically addressing adult patients with solid tumors and nonmyeloid malignancies.

Original languageEnglish (US)
Pages (from-to)64-83
Number of pages20
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume7
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Chemotherapy
  • Fever
  • Myeloid growth factors
  • NCCN clinical practice guidelines
  • Neutropenia

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Crawford, J., Armitage, J., Balducci, L., Bennett, C., Blayney, D. W., Cataland, S. R., Dale, D. C., Demetri, G. D., Erba, H. P., Foran, J., Freifeld, A. G., Goemann, M., Heaney, M. L., Htoy, S., Hudock, S., Kloth, D. D., Kuter, D. J., Lyman, G. H., Michaud, L. B., ... Wong, M. K. (2009). Myeloid growth factors. JNCCN Journal of the National Comprehensive Cancer Network, 7(1), 64-83. https://doi.org/10.6004/jnccn.2009.0006