Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: Concomitant occurrence of two molecularly distinct diseases

Yenny Alejandra Moreno Vanegas, Abdel Ghani M. Azzouqa, David M. Menke, James M. Foran, Prakash Vishnu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Concurrent presentation of acute promyelocytic leukemia (APL) with other hematologic diseases in the absence of previous chemotherapy or ionizing radiotherapy treatment is very rare. We present a case of simultaneous occurrence of APL with myelodysplastic syndrome (MDS)-related acute myeloid leukemia (AML). A 43-yearold female presented with 3 month of history fatigue, night sweats, chills and pancytopenia. Bone marrow aspirate and biopsy demonstrated 20% myeloid blasts with dysplastic changes admixed with abnormal promyelocytes. Cytogenetic analysis showed tetraploidy and deletion in chromosomes 5q and 7q and polymerase chain reaction showed presence of PML/RARA mRNA transcripts, confirming the presence of concurrent APL and MDS-related AML. Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid. This is the first case to be reported in the literature of concurrent occurrence of APL with MDS-related AML. Treatment with 7 + 3 regimen and ATRA was successful in inducing complete remission.

Original languageEnglish (US)
Article number7658
Pages (from-to)59-61
Number of pages3
JournalHematology Reports
Volume10
Issue number3
DOIs
StatePublished - Sep 5 2018

Keywords

  • Acute myeloid leukemia
  • Acute promyelocytic leukemia
  • Concurrent
  • Management
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology

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