TY - JOUR
T1 - Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia
T2 - Concomitant occurrence of two molecularly distinct diseases
AU - Vanegas, Yenny Alejandra Moreno
AU - Azzouqa, Abdel Ghani M.
AU - Menke, David M.
AU - Foran, James M.
AU - Vishnu, Prakash
N1 - Publisher Copyright:
© Y.A.M. Vanegas et al., 2018.
PY - 2018/9/5
Y1 - 2018/9/5
N2 - Concurrent presentation of acute promyelocytic leukemia (APL) with other hematologic diseases in the absence of previous chemotherapy or ionizing radiotherapy treatment is very rare. We present a case of simultaneous occurrence of APL with myelodysplastic syndrome (MDS)-related acute myeloid leukemia (AML). A 43-yearold female presented with 3 month of history fatigue, night sweats, chills and pancytopenia. Bone marrow aspirate and biopsy demonstrated 20% myeloid blasts with dysplastic changes admixed with abnormal promyelocytes. Cytogenetic analysis showed tetraploidy and deletion in chromosomes 5q and 7q and polymerase chain reaction showed presence of PML/RARA mRNA transcripts, confirming the presence of concurrent APL and MDS-related AML. Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid. This is the first case to be reported in the literature of concurrent occurrence of APL with MDS-related AML. Treatment with 7 + 3 regimen and ATRA was successful in inducing complete remission.
AB - Concurrent presentation of acute promyelocytic leukemia (APL) with other hematologic diseases in the absence of previous chemotherapy or ionizing radiotherapy treatment is very rare. We present a case of simultaneous occurrence of APL with myelodysplastic syndrome (MDS)-related acute myeloid leukemia (AML). A 43-yearold female presented with 3 month of history fatigue, night sweats, chills and pancytopenia. Bone marrow aspirate and biopsy demonstrated 20% myeloid blasts with dysplastic changes admixed with abnormal promyelocytes. Cytogenetic analysis showed tetraploidy and deletion in chromosomes 5q and 7q and polymerase chain reaction showed presence of PML/RARA mRNA transcripts, confirming the presence of concurrent APL and MDS-related AML. Induction chemotherapy with cytarabine and daunorubicin was initiated along with all-trans retinoic acid. This is the first case to be reported in the literature of concurrent occurrence of APL with MDS-related AML. Treatment with 7 + 3 regimen and ATRA was successful in inducing complete remission.
KW - Acute myeloid leukemia
KW - Acute promyelocytic leukemia
KW - Concurrent
KW - Management
KW - Myelodysplastic syndrome
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U2 - 10.4081/hr.2018.7658
DO - 10.4081/hr.2018.7658
M3 - Article
AN - SCOPUS:85053153814
SN - 2038-8322
VL - 10
SP - 59
EP - 61
JO - Hematology Reports
JF - Hematology Reports
IS - 3
M1 - 7658
ER -