"Myelodysplasia," myeloneuropathy, and copper deficiency

Neeraj Kumar, Michelle A. Elliott, James Hoyer, Charles M. Harper, J. Eric Ahlskog, Robert L. Phyliky

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

We describe a patient with a suspected myelodysplastic syndrome that developed in association with a neurologic disorder resembling subacute combined degeneration but without vitamin B12 deficiency. Ultimately, the hematologic manifestations and the neurologic syndrome were linked to severe copper deficiency. Prompt and complete reversal of the hematologic abnormalities occurred with copper replacement. Serum copper determination should be included in the work-up of patients with anemia and leukopenia of unclear etiology who have associated myeloneuropathy. The hematologic picture can resemble sideroblastic anemia or myelodysplastic syndrome. Hyperzincemia can be an accompanying abnormality even without exogenous zinc ingestion. The reason for the copper deficiency may not be evident.

Original languageEnglish (US)
Pages (from-to)943-946
Number of pages4
JournalMayo Clinic Proceedings
Volume80
Issue number7
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Copper
Myelodysplastic Syndromes
Subacute Combined Degeneration
Sideroblastic Anemia
Vitamin B 12 Deficiency
Leukopenia
Neurologic Manifestations
Nervous System Diseases
Zinc
Anemia
Eating
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kumar, N., Elliott, M. A., Hoyer, J., Harper, C. M., Ahlskog, J. E., & Phyliky, R. L. (2005). "Myelodysplasia," myeloneuropathy, and copper deficiency. Mayo Clinic Proceedings, 80(7), 943-946. https://doi.org/10.4065/80.7.943

"Myelodysplasia," myeloneuropathy, and copper deficiency. / Kumar, Neeraj; Elliott, Michelle A.; Hoyer, James; Harper, Charles M.; Ahlskog, J. Eric; Phyliky, Robert L.

In: Mayo Clinic Proceedings, Vol. 80, No. 7, 01.01.2005, p. 943-946.

Research output: Contribution to journalArticle

Kumar, N, Elliott, MA, Hoyer, J, Harper, CM, Ahlskog, JE & Phyliky, RL 2005, '"Myelodysplasia," myeloneuropathy, and copper deficiency', Mayo Clinic Proceedings, vol. 80, no. 7, pp. 943-946. https://doi.org/10.4065/80.7.943
Kumar N, Elliott MA, Hoyer J, Harper CM, Ahlskog JE, Phyliky RL. "Myelodysplasia," myeloneuropathy, and copper deficiency. Mayo Clinic Proceedings. 2005 Jan 1;80(7):943-946. https://doi.org/10.4065/80.7.943
Kumar, Neeraj ; Elliott, Michelle A. ; Hoyer, James ; Harper, Charles M. ; Ahlskog, J. Eric ; Phyliky, Robert L. / "Myelodysplasia," myeloneuropathy, and copper deficiency. In: Mayo Clinic Proceedings. 2005 ; Vol. 80, No. 7. pp. 943-946.
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