Mycophenolate mofetil-induced segmental colitis mimicking ischemic colitis

Kevin Johal; Shiva K. Ratuapli; Dora M. Lam-Himlin; Suryakanth R. Gurudu

doi:10.1159/000360847

Mycophenolate mofetil-induced segmental colitis mimicking ischemic colitis

Kevin Johal, Shiva K. Ratuapli, Dora M. Lam-Himlin, Suryakanth R. Gurudu

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Mycophenolate mofetil (MMF) is a commonly used drug in the prevention of allograft rejection in patients with solid organ transplants. Although diffuse colitis has been described in MMF-related colitis, segmental colitis has not been reported. We report the case of a 64-year-old male on MMF therapy who presented for evaluation of afebrile diarrhea and abdominal pain. Flexible sigmoidoscopy revealed a segmental erythematous mucosa with ulceration in the sigmoid colon, descending colon, splenic flexure and proximal transverse colon. Biopsies of these areas showed dilated damaged crypts, eosinophilic epithelial changes and crypt abscesses with apoptotic bodies consistent with MMF-induced injury. MMF was discontinued, leading to a significant improvement of his symptoms.

Original language	English (US)
Pages (from-to)	95-100
Number of pages	6
Journal	Case Reports in Gastroenterology
Volume	8
Issue number	1
DOIs	https://doi.org/10.1159/000360847
State	Published - 2014

Keywords

Apoptosis
Ischemic colitis
Mycophenolate mofetil
Segmental colitis

ASJC Scopus subject areas

Gastroenterology

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10.1159/000360847

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abstract = "Mycophenolate mofetil (MMF) is a commonly used drug in the prevention of allograft rejection in patients with solid organ transplants. Although diffuse colitis has been described in MMF-related colitis, segmental colitis has not been reported. We report the case of a 64-year-old male on MMF therapy who presented for evaluation of afebrile diarrhea and abdominal pain. Flexible sigmoidoscopy revealed a segmental erythematous mucosa with ulceration in the sigmoid colon, descending colon, splenic flexure and proximal transverse colon. Biopsies of these areas showed dilated damaged crypts, eosinophilic epithelial changes and crypt abscesses with apoptotic bodies consistent with MMF-induced injury. MMF was discontinued, leading to a significant improvement of his symptoms.",

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AU - Ratuapli, Shiva K.

AU - Lam-Himlin, Dora M.

AU - Gurudu, Suryakanth R.

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AB - Mycophenolate mofetil (MMF) is a commonly used drug in the prevention of allograft rejection in patients with solid organ transplants. Although diffuse colitis has been described in MMF-related colitis, segmental colitis has not been reported. We report the case of a 64-year-old male on MMF therapy who presented for evaluation of afebrile diarrhea and abdominal pain. Flexible sigmoidoscopy revealed a segmental erythematous mucosa with ulceration in the sigmoid colon, descending colon, splenic flexure and proximal transverse colon. Biopsies of these areas showed dilated damaged crypts, eosinophilic epithelial changes and crypt abscesses with apoptotic bodies consistent with MMF-induced injury. MMF was discontinued, leading to a significant improvement of his symptoms.

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Mycophenolate mofetil-induced segmental colitis mimicking ischemic colitis

Abstract

Keywords

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