Abstract
Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-59 |
| Number of pages | 5 |
| Journal | Seminars in Arthritis and Rheumatism |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 1 2015 |
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Keywords
- Mycophenolate mofetil
- PCNSV
- Therapy
- Vasculitis
ASJC Scopus subject areas
- Rheumatology
- Anesthesiology and Pain Medicine
Cite this
Mycophenolate mofetil in primary central nervous system vasculitis. / Salvarani, Carlo; Brown, Robert D Jr.; Christianson, Teresa J H; Huston, John III; Giannini, Caterina; Miller, Dylan V.; Muratore, Francesco; Hunder, Gene G.
In: Seminars in Arthritis and Rheumatism, Vol. 45, No. 1, 01.08.2015, p. 55-59.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mycophenolate mofetil in primary central nervous system vasculitis
AU - Salvarani, Carlo
AU - Brown, Robert D Jr.
AU - Christianson, Teresa J H
AU - Huston, John III
AU - Giannini, Caterina
AU - Miller, Dylan V.
AU - Muratore, Francesco
AU - Hunder, Gene G.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.
AB - Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.
KW - Mycophenolate mofetil
KW - PCNSV
KW - Therapy
KW - Vasculitis
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UR - http://www.scopus.com/inward/citedby.url?scp=84937737529&partnerID=8YFLogxK
U2 - 10.1016/j.semarthrit.2015.02.008
DO - 10.1016/j.semarthrit.2015.02.008
M3 - Article
VL - 45
SP - 55
EP - 59
JO - Seminars in Arthritis and Rheumatism
JF - Seminars in Arthritis and Rheumatism
SN - 0049-0172
IS - 1
ER -