Mycophenolate mofetil in primary central nervous system vasculitis

Carlo Salvarani; Robert D Jr. Brown; Teresa J H Christianson; John III Huston; Caterina Giannini; Dylan V. Miller; Francesco Muratore; Gene G. Hunder

doi:10.1016/j.semarthrit.2015.02.008

Mycophenolate mofetil in primary central nervous system vasculitis

Carlo Salvarani, Robert D Jr. Brown, Teresa J H Christianson, John III Huston, Caterina Giannini, Dylan V. Miller, Francesco Muratore, Gene G. Hunder

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.

Original language	English (US)
Pages (from-to)	55-59
Number of pages	5
Journal	Seminars in Arthritis and Rheumatism
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.semarthrit.2015.02.008
State	Published - Aug 1 2015

Keywords

Mycophenolate mofetil
PCNSV
Therapy
Vasculitis

ASJC Scopus subject areas

Rheumatology
Anesthesiology and Pain Medicine

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10.1016/j.semarthrit.2015.02.008

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title = "Mycophenolate mofetil in primary central nervous system vasculitis",

abstract = "Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.",

keywords = "Mycophenolate mofetil, PCNSV, Therapy, Vasculitis",

author = "Carlo Salvarani and Brown, {Robert D Jr.} and Christianson, {Teresa J H} and Huston, {John III} and Caterina Giannini and Miller, {Dylan V.} and Francesco Muratore and Hunder, {Gene G.}",

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AU - Salvarani, Carlo

AU - Brown, Robert D Jr.

AU - Christianson, Teresa J H

AU - Huston, John III

AU - Giannini, Caterina

AU - Miller, Dylan V.

AU - Muratore, Francesco

AU - Hunder, Gene G.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.

AB - Objective: To evaluate the efficacy and safety of mycophenolate mofetil (MMF) in adult primary central nervous system vasculitis (PCNSV). Methods: We studied a cohort of 163 patients with PCNSV who were seen at the Mayo Clinic from 1983 to 2011. We compared patients treated with MMF and those receiving other therapies. Results: We identified 16 patients treated with MMF. MMF in combination with GCs achieved a favorable response in most patients. A significant proportion of patients treated with MMF had a less severe disability at last follow-up compared to those receiving other therapies (p = 0.023) and cyclophosphamide and prednisone (p = 0.017). No statistically significant differences were observed regarding relapses and ability to discontinue therapy at last follow-up. A trend to a more favorable treatment response was observed in patients treated with MMF compared to those treated with other therapies (p = 0.075). Only 1 patient suspended MMF for severe leukopenia. Conclusion: MMF seems to be an effective and safe therapy for adult PCNSV.

KW - Mycophenolate mofetil

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KW - Therapy

KW - Vasculitis

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Mycophenolate mofetil in primary central nervous system vasculitis

Abstract

Keywords

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