Myasthenia gravis in the cat.

R. J. Joseph, J. M. Carrillo, Vanda A Lennon

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Myasthenia gravis (MG) was diagnosed in four cats--one had an apparently congenital form and three had the acquired autoimmune form. All four cats were examined because of episodes of weakness including gait abnormalities, voice change, neck ventroflexion, and regurgitation. Palpebral reflexes were absent in all cats. Administration of edrophonium chloride resulted in transient resolution of clinical signs in all four cats. Three cats were tested for the presence of serum autoantibodies against acetylcholine receptor (AChR) by radioimmunoassay. Two cats with acquired MG had anti-AChR antibody titers of 10.5 and 96.8 nmol/l (normal, less than or equal to 0.03 nmol/l). Antibodies were not detected in the cat with presumptive congenital MG. All four cats were treated with pyridostigmine bromide. Two cats with acquired MG were euthanatized because of clinical deterioration. The third cat with acquired MG has been asymptomatic since 2 months after diagnosis. The cat with presumed congenital MG is alive 3 years after diagnosis.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalJournal of veterinary internal medicine / American College of Veterinary Internal Medicine
Volume2
Issue number2
StatePublished - Apr 1988

Fingerprint

Myasthenia Gravis
Cats
cats
Congenital Myasthenic Syndromes
cholinergic receptors
Cholinergic Receptors
Edrophonium
Pyridostigmine Bromide
Abnormal Reflexes
antibodies
autoantibodies
eyelids
Antibodies
Eyelids
gait
radioimmunoassays
bromides
reflexes
Gait
Autoantibodies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Myasthenia gravis in the cat. / Joseph, R. J.; Carrillo, J. M.; Lennon, Vanda A.

In: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine, Vol. 2, No. 2, 04.1988, p. 75-79.

Research output: Contribution to journalArticle

@article{586299b1482246f8a57e85f893f786d9,
title = "Myasthenia gravis in the cat.",
abstract = "Myasthenia gravis (MG) was diagnosed in four cats--one had an apparently congenital form and three had the acquired autoimmune form. All four cats were examined because of episodes of weakness including gait abnormalities, voice change, neck ventroflexion, and regurgitation. Palpebral reflexes were absent in all cats. Administration of edrophonium chloride resulted in transient resolution of clinical signs in all four cats. Three cats were tested for the presence of serum autoantibodies against acetylcholine receptor (AChR) by radioimmunoassay. Two cats with acquired MG had anti-AChR antibody titers of 10.5 and 96.8 nmol/l (normal, less than or equal to 0.03 nmol/l). Antibodies were not detected in the cat with presumptive congenital MG. All four cats were treated with pyridostigmine bromide. Two cats with acquired MG were euthanatized because of clinical deterioration. The third cat with acquired MG has been asymptomatic since 2 months after diagnosis. The cat with presumed congenital MG is alive 3 years after diagnosis.",
author = "Joseph, {R. J.} and Carrillo, {J. M.} and Lennon, {Vanda A}",
year = "1988",
month = "4",
language = "English (US)",
volume = "2",
pages = "75--79",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Myasthenia gravis in the cat.

AU - Joseph, R. J.

AU - Carrillo, J. M.

AU - Lennon, Vanda A

PY - 1988/4

Y1 - 1988/4

N2 - Myasthenia gravis (MG) was diagnosed in four cats--one had an apparently congenital form and three had the acquired autoimmune form. All four cats were examined because of episodes of weakness including gait abnormalities, voice change, neck ventroflexion, and regurgitation. Palpebral reflexes were absent in all cats. Administration of edrophonium chloride resulted in transient resolution of clinical signs in all four cats. Three cats were tested for the presence of serum autoantibodies against acetylcholine receptor (AChR) by radioimmunoassay. Two cats with acquired MG had anti-AChR antibody titers of 10.5 and 96.8 nmol/l (normal, less than or equal to 0.03 nmol/l). Antibodies were not detected in the cat with presumptive congenital MG. All four cats were treated with pyridostigmine bromide. Two cats with acquired MG were euthanatized because of clinical deterioration. The third cat with acquired MG has been asymptomatic since 2 months after diagnosis. The cat with presumed congenital MG is alive 3 years after diagnosis.

AB - Myasthenia gravis (MG) was diagnosed in four cats--one had an apparently congenital form and three had the acquired autoimmune form. All four cats were examined because of episodes of weakness including gait abnormalities, voice change, neck ventroflexion, and regurgitation. Palpebral reflexes were absent in all cats. Administration of edrophonium chloride resulted in transient resolution of clinical signs in all four cats. Three cats were tested for the presence of serum autoantibodies against acetylcholine receptor (AChR) by radioimmunoassay. Two cats with acquired MG had anti-AChR antibody titers of 10.5 and 96.8 nmol/l (normal, less than or equal to 0.03 nmol/l). Antibodies were not detected in the cat with presumptive congenital MG. All four cats were treated with pyridostigmine bromide. Two cats with acquired MG were euthanatized because of clinical deterioration. The third cat with acquired MG has been asymptomatic since 2 months after diagnosis. The cat with presumed congenital MG is alive 3 years after diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=0023996120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023996120&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 75

EP - 79

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 2

ER -