TY - JOUR
T1 - My Migraine Voice survey
T2 - A global study of disease burden among individuals with migraine for whom preventive treatments have failed
AU - Martelletti, Paolo
AU - Schwedt, Todd J.
AU - Lanteri-Minet, Michel
AU - Quintana, Rebeca
AU - Carboni, Veruska
AU - Diener, Hans Christoph
AU - Ruiz De La Torre, Elena
AU - Craven, Audrey
AU - Rasmussen, Annette Vangaa
AU - Evans, Simon
AU - Laflamme, Annik K.
AU - Fink, Rachel
AU - Walsh, Donna
AU - Dumas, Paula
AU - Vo, Pamela
N1 - Funding Information:
• Todd Schwedt receives research funding from the National Institutes of Health, the U.S. Department of Defense, the Patient Centered Outcomes Research Institute, the American Migraine Foundation, Arizona State University, and the Mayo Clinic. He serves as a consultant or on advisory boards for Alder, Allergan, Amgen, ATI, Aural Analytics, Avanir, Eli Lilly, the International Concussion Society, Ipsen Bioscience, Nocira, Novartis, Promius Pharma, Second Opinion, Teva. He is on the Board of Directors for the American Headache Society and the International Headache Society.
Funding Information:
• Michel Lanteri-Minet receives research funding from the Direction Générale de la Santé, the Agence Nationale de Sécurité des Médicaments, the Société Française de la Douleur, the Fondation Apicil, the Migraine Foundation. He serves as a consultant or on advisory boards for Allergan, Amgen, Astellas, ATI, BMS, Boehringer, Boston Scientific, CoLucid, Convergence, Glaxo-SmithKline, Grunenthal, Lilly, Medtronic, Menarini, MSD, Novartis, Pfizer, ReckittBenckiser, Saint-Jude, Sanofi-Aventis, Teva, UCB, Zambon.
Funding Information:
This study was sponsored by Novartis Pharma AG; Novartis supported the design of the study, data collection, the data analysis, the manuscript development and submission.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/11/27
Y1 - 2018/11/27
N2 - Background: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering from ≥4 monthly migraine days (MMDs) with a history of prophylactic treatment failure. Methods: This study was conducted worldwide (31 countries across North and South Americas, Europe, the Middle East and Northern Africa, and the Asia-Pacific region) using an online survey administered to adults with migraine who reported ≥4 MMDs in the 3 months preceding survey administration, with pre-specified criteria of 90% having used preventive migraine treatment (80% with history of ≥1 treatment failure). Prophylactic treatment failure was defined as a reported change in preventive medication by individuals with migraine for any reason, at least once. Results: In total, 11,266 individuals participated in the survey. Seventy-four percent of the participants reported spending time in darkness/isolation due to migraine (average: 19 h/month). While 85% of all respondents reported negative aspects of living with migraine (feeling helpless, depressed, not understood), sleeping difficulties (83%), and fear of the next attack (55%), 57% shared ≥1 positive aspect (learning to cope, becoming a stronger person). Forty-nine percent reported feeling limited in daily activities throughout all migraine phases. Migraine impact on professional, private, or social domains was reported by 87% of respondents (51% in all domains). In the previous 12 months, 38% of respondents had visited the emergency department (average: 3.3 visits), whereas 23% stayed in hospital overnight (average: 3.2 nights) due to migraine. Conclusions: The burden of migraine is substantial among this cohort of individuals with at least 4 migraine days per month and for whom at least 1 preventive migraine treatment had failed. Interestingly, respondents reported some positive aspects in their migraine journey; the greater resilience and strength brought on by coping with migraine suggests that if future treatments could address existing unmet needs, these individuals with migraine will be able to maximize their contribution to society.
AB - Background: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering from ≥4 monthly migraine days (MMDs) with a history of prophylactic treatment failure. Methods: This study was conducted worldwide (31 countries across North and South Americas, Europe, the Middle East and Northern Africa, and the Asia-Pacific region) using an online survey administered to adults with migraine who reported ≥4 MMDs in the 3 months preceding survey administration, with pre-specified criteria of 90% having used preventive migraine treatment (80% with history of ≥1 treatment failure). Prophylactic treatment failure was defined as a reported change in preventive medication by individuals with migraine for any reason, at least once. Results: In total, 11,266 individuals participated in the survey. Seventy-four percent of the participants reported spending time in darkness/isolation due to migraine (average: 19 h/month). While 85% of all respondents reported negative aspects of living with migraine (feeling helpless, depressed, not understood), sleeping difficulties (83%), and fear of the next attack (55%), 57% shared ≥1 positive aspect (learning to cope, becoming a stronger person). Forty-nine percent reported feeling limited in daily activities throughout all migraine phases. Migraine impact on professional, private, or social domains was reported by 87% of respondents (51% in all domains). In the previous 12 months, 38% of respondents had visited the emergency department (average: 3.3 visits), whereas 23% stayed in hospital overnight (average: 3.2 nights) due to migraine. Conclusions: The burden of migraine is substantial among this cohort of individuals with at least 4 migraine days per month and for whom at least 1 preventive migraine treatment had failed. Interestingly, respondents reported some positive aspects in their migraine journey; the greater resilience and strength brought on by coping with migraine suggests that if future treatments could address existing unmet needs, these individuals with migraine will be able to maximize their contribution to society.
KW - Burden
KW - Global survey
KW - Migraine
KW - Migraine experience
KW - Work productivity
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U2 - 10.1186/s10194-018-0946-z
DO - 10.1186/s10194-018-0946-z
M3 - Article
C2 - 30482181
AN - SCOPUS:85057260441
VL - 19
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
SN - 1129-2369
IS - 1
M1 - 115
ER -