Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer

Hoon Yang Sei, Leah E. Mechanic, Ping Yang, Maria Teresa Landi, Elise D. Bowman, Jason Wampfler, Daoud Meerzaman, Man Hong Kyeong, Felicia Mann, Tatiana Dracheva, Junya Fukuoka, William Travis, Neil E. Caporaso, Curtis C. Harris, Jin Jen

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

We evaluated somatic genetic alterations in the kinase domain of the EGFR gene in the tumors of 219 non-small cell lung cancer patients of primarily Caucasian and African American origins. We identified 26 patients (12%) whose tumors had a mutation in the EGFR gene, and 11 (5%) patients carried novel genomic variations consistent with germ-line polymorphisms. All but one mutation were identified in Caucasian patients affected with adenocarcinoma. EGFR mutations were more frequent in women and in nonsmokers, but a significant portion of the affected patients were men (12 of 26) and current or past smokers accounted for half of the patients affected (13 of 26). Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors.

Original languageEnglish (US)
Pages (from-to)2106-2110
Number of pages5
JournalClinical Cancer Research
Volume11
Issue number6
DOIs
StatePublished - Mar 15 2005

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Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
erbB-1 Genes
Neoplasms
Germ Cells
African Americans
Adenocarcinoma
Phosphotransferases

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. / Sei, Hoon Yang; Mechanic, Leah E.; Yang, Ping; Landi, Maria Teresa; Bowman, Elise D.; Wampfler, Jason; Meerzaman, Daoud; Kyeong, Man Hong; Mann, Felicia; Dracheva, Tatiana; Fukuoka, Junya; Travis, William; Caporaso, Neil E.; Harris, Curtis C.; Jen, Jin.

In: Clinical Cancer Research, Vol. 11, No. 6, 15.03.2005, p. 2106-2110.

Research output: Contribution to journalArticle

Sei, HY, Mechanic, LE, Yang, P, Landi, MT, Bowman, ED, Wampfler, J, Meerzaman, D, Kyeong, MH, Mann, F, Dracheva, T, Fukuoka, J, Travis, W, Caporaso, NE, Harris, CC & Jen, J 2005, 'Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer', Clinical Cancer Research, vol. 11, no. 6, pp. 2106-2110. https://doi.org/10.1158/1078-0432.CCR-04-1853
Sei, Hoon Yang ; Mechanic, Leah E. ; Yang, Ping ; Landi, Maria Teresa ; Bowman, Elise D. ; Wampfler, Jason ; Meerzaman, Daoud ; Kyeong, Man Hong ; Mann, Felicia ; Dracheva, Tatiana ; Fukuoka, Junya ; Travis, William ; Caporaso, Neil E. ; Harris, Curtis C. ; Jen, Jin. / Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. In: Clinical Cancer Research. 2005 ; Vol. 11, No. 6. pp. 2106-2110.
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