Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer

Viji Shridhar; Sylvie Rivard; Xiaohong Wang; Ravi Shridhar; Christa Paisley; Chadwick Mullins; Laura Beirnat; Michael Dugan; Fazlul Sarkar; Orlando J. Miller; Vainutis K. Vaitkevicius; David I. Smith

doi:10.1038/sj.onc.1201054

Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer

Viji Shridhar, Sylvie Rivard, Xiaohong Wang, Ravi Shridhar, Christa Paisley, Chadwick Mullins, Laura Beirnat, Michael Dugan, Fazlul Sarkar, Orlando J. Miller, Vainutis K. Vaitkevicius, David I. Smith

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The ARP gene encodes a highly conserved arginine-rich protein from chromosomal band 3p21.1. At the cytogenetic level this region is frequently deleted in a variety of different solid tumors, although not in pancreatic cancer. We have reported the presence of a specific mutation (ATG₅₀ → AGG) or deletion of codon 50 of the ARP gene in different tumor types. In the present study, we have observed mutations involving codon 50 in 11 of 37 pancreatic tumors. The frequency of codon 50 mutation is roughly the same in pancreatic tumors as in the other types of previously examined. In addition, we have detected mutations at codon multiple PCR subclones in two other pancreatic tumors. Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.

Original language	English (US)
Pages (from-to)	2213-2216
Number of pages	4
Journal	Oncogene
Volume	14
Issue number	18
DOIs	https://doi.org/10.1038/sj.onc.1201054
State	Published - 1997

Keywords

ARP gene
Pancreatic adenocarcinoma
Recurring mutations

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1038/sj.onc.1201054

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title = "Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer",

abstract = "The ARP gene encodes a highly conserved arginine-rich protein from chromosomal band 3p21.1. At the cytogenetic level this region is frequently deleted in a variety of different solid tumors, although not in pancreatic cancer. We have reported the presence of a specific mutation (ATG50 → AGG) or deletion of codon 50 of the ARP gene in different tumor types. In the present study, we have observed mutations involving codon 50 in 11 of 37 pancreatic tumors. The frequency of codon 50 mutation is roughly the same in pancreatic tumors as in the other types of previously examined. In addition, we have detected mutations at codon multiple PCR subclones in two other pancreatic tumors. Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.",

keywords = "ARP gene, Pancreatic adenocarcinoma, Recurring mutations",

author = "Viji Shridhar and Sylvie Rivard and Xiaohong Wang and Ravi Shridhar and Christa Paisley and Chadwick Mullins and Laura Beirnat and Michael Dugan and Fazlul Sarkar and Miller, {Orlando J.} and Vaitkevicius, {Vainutis K.} and Smith, {David I.}",

note = "Funding Information: This work was supported by NIH Grant CA48031 (to DIS) and by the Marlin Pemberton Fund for Pancreatic Cancer Research.",

year = "1997",

doi = "10.1038/sj.onc.1201054",

language = "English (US)",

volume = "14",

pages = "2213--2216",

journal = "Oncogene",

issn = "0950-9232",

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T1 - Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer

AU - Shridhar, Viji

AU - Rivard, Sylvie

AU - Wang, Xiaohong

AU - Shridhar, Ravi

AU - Paisley, Christa

AU - Mullins, Chadwick

AU - Beirnat, Laura

AU - Dugan, Michael

AU - Sarkar, Fazlul

AU - Miller, Orlando J.

AU - Vaitkevicius, Vainutis K.

AU - Smith, David I.

N1 - Funding Information: This work was supported by NIH Grant CA48031 (to DIS) and by the Marlin Pemberton Fund for Pancreatic Cancer Research.

PY - 1997

Y1 - 1997

N2 - The ARP gene encodes a highly conserved arginine-rich protein from chromosomal band 3p21.1. At the cytogenetic level this region is frequently deleted in a variety of different solid tumors, although not in pancreatic cancer. We have reported the presence of a specific mutation (ATG50 → AGG) or deletion of codon 50 of the ARP gene in different tumor types. In the present study, we have observed mutations involving codon 50 in 11 of 37 pancreatic tumors. The frequency of codon 50 mutation is roughly the same in pancreatic tumors as in the other types of previously examined. In addition, we have detected mutations at codon multiple PCR subclones in two other pancreatic tumors. Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.

AB - The ARP gene encodes a highly conserved arginine-rich protein from chromosomal band 3p21.1. At the cytogenetic level this region is frequently deleted in a variety of different solid tumors, although not in pancreatic cancer. We have reported the presence of a specific mutation (ATG50 → AGG) or deletion of codon 50 of the ARP gene in different tumor types. In the present study, we have observed mutations involving codon 50 in 11 of 37 pancreatic tumors. The frequency of codon 50 mutation is roughly the same in pancreatic tumors as in the other types of previously examined. In addition, we have detected mutations at codon multiple PCR subclones in two other pancreatic tumors. Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.

KW - ARP gene

KW - Pancreatic adenocarcinoma

KW - Recurring mutations

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Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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