Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer

Viji Shridhar, Sylvie Rivard, Xiaohong Wang, Ravi Shridhar, Christa Paisley, Chadwick Mullins, Laura Beirnat, Michael Dugan, Fazlul Sarkar, Orlando J. Miller, Vainutis K. Vaitkevicius, David I. Smith

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The ARP gene encodes a highly conserved arginine-rich protein from chromosomal band 3p21.1. At the cytogenetic level this region is frequently deleted in a variety of different solid tumors, although not in pancreatic cancer. We have reported the presence of a specific mutation (ATG50 → AGG) or deletion of codon 50 of the ARP gene in different tumor types. In the present study, we have observed mutations involving codon 50 in 11 of 37 pancreatic tumors. The frequency of codon 50 mutation is roughly the same in pancreatic tumors as in the other types of previously examined. In addition, we have detected mutations at codon multiple PCR subclones in two other pancreatic tumors. Mutations in the ARP gene are thus commonly observed in pancreatic cancer, as well as many other cancers.

Original languageEnglish (US)
Pages (from-to)2213-2216
Number of pages4
JournalOncogene
Volume14
Issue number18
DOIs
StatePublished - Jan 1 1997

Keywords

  • ARP gene
  • Pancreatic adenocarcinoma
  • Recurring mutations

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Shridhar, V., Rivard, S., Wang, X., Shridhar, R., Paisley, C., Mullins, C., Beirnat, L., Dugan, M., Sarkar, F., Miller, O. J., Vaitkevicius, V. K., & Smith, D. I. (1997). Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. Oncogene, 14(18), 2213-2216. https://doi.org/10.1038/sj.onc.1201054