Abstract
With the application of adequately sensitive tests, it is now becoming evident that more than 90% of patients with conventionally-defined polycythemia vera (PV) carry the somatic JAK2V617F mutation in their granulocytes. However, the specific mutation is also found in other classic and atypical myeloproliferative disorders (MPD), albeit at a lesser frequency. In contrast, JAK2V617F has not been reported in patients with either reactive myeloproliferation or lymphoid disorders. Therefore, mutation screening for JAK2V617F can be considered as a myeloid-specific clonality assay and it is diagnostically most useful in the evaluation of "polycythemia".
Original language | English (US) |
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Pages (from-to) | 739-744 |
Number of pages | 6 |
Journal | Leukemia Research |
Volume | 30 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2006 |
Keywords
- Diagnosis
- JAK2 mutation
- Polycythemia
- Thrombocytosis
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research