@article{0e9629caf5d54fec966c340ab7a51ccb,
title = "Mutant alleles of HD improve the life span of p53-/- mice",
abstract = "Loss of function mutations in the p53 tumor suppressor gene predispose mice and humans to cancer, resulting in abbreviated life spans. A dominant mutation in the murine HD gene, similar to mutations that cause Huntington's disease in humans, reverses some of the effects of p53 mutations on longevity. We attribute this to the enhanced apoptotic effect of the expanded polyglutamine region in the HD protein on proliferating cells lacking p53.",
keywords = "Cancer, Huntington's disease, Longevity, Skewed sex ratio",
author = "Amy Ryan and Heidi Scrable",
note = "Funding Information: We thank W. Gluba and Dr. B. Maier for excellent technical support. We thank Dr. Scott Zeitlin for the Hdh Q140/Q140 mice. H.S. thanks Dr. George Martin for critical reading of an earlier version of the manuscript. We also thank the flow cytometry core facility in the Department of Microbiology at the University of Virginia for their service. This work was supported by a National Research Service Award predoctoral fellowship from NIMH/NIH (A.B.R.) and the Hereditary Disease Foundation (H.S.). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",
year = "2008",
month = apr,
doi = "10.1016/j.mad.2007.12.003",
language = "English (US)",
volume = "129",
pages = "238--241",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "4",
}