Mutant alleles of HD improve the life span of p53-/- mice

Amy Ryan; Heidi Scrable

doi:10.1016/j.mad.2007.12.003

Mutant alleles of HD improve the life span of p53^-/- mice

Amy Ryan, Heidi Scrable

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Loss of function mutations in the p53 tumor suppressor gene predispose mice and humans to cancer, resulting in abbreviated life spans. A dominant mutation in the murine HD gene, similar to mutations that cause Huntington's disease in humans, reverses some of the effects of p53 mutations on longevity. We attribute this to the enhanced apoptotic effect of the expanded polyglutamine region in the HD protein on proliferating cells lacking p53.

Original language	English (US)
Pages (from-to)	238-241
Number of pages	4
Journal	Mechanisms of Ageing and Development
Volume	129
Issue number	4
DOIs	https://doi.org/10.1016/j.mad.2007.12.003
State	Published - Apr 1 2008

Keywords

Cancer
Huntington's disease
Longevity
Skewed sex ratio

ASJC Scopus subject areas

Aging
Developmental Biology

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Ryan, A., & Scrable, H. (2008). Mutant alleles of HD improve the life span of p53^-/- mice. Mechanisms of Ageing and Development, 129(4), 238-241. https://doi.org/10.1016/j.mad.2007.12.003

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