Musculoskeletal manifestations of inflammatory bowel disease

Leonidas A. Bourikas, Konstantinos Papadakis

Research output: Contribution to journalReview article

42 Scopus citations


Extraintestinal manifestations develop in ≈25% of patients with inflammatory bowel disease (IBD). Musculoskeletal symptoms are the most common extraintestinal manifestations of IBD, often associated with colonic involvement, and present as either articular (arthritis) or periarticular inflammation including enthesitis, myositis, or soft tissue rheumatism (fibromyalgia). Musculoskeletal manifestations can precede or be synchronous with the development of bowel disease or develop following the diagnosis of IBD. Their clinical course often correlates with IBD activity but it can also be independent of the activity of bowel disease. Controlling intestinal inflammation remains the cornerstone therapeutic approach for the musculoskeletal manifestations of IBD.

Original languageEnglish (US)
Pages (from-to)1915-1924
Number of pages10
JournalInflammatory Bowel Diseases
Issue number12
StatePublished - Dec 29 2009
Externally publishedYes



  • Inflammatory bowel disease
  • Intestinal inflammation
  • Musculoskeletal manifestations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

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