Abstract
Objective: We sought to determine whether muscle density, an index of skeletal muscle fat content, was predictive of 2-year changes in weight-bearing bone parameters in young girls. Methods: Two-year prospective data from 248 girls, aged 8-13 years at baseline. Peripheral quantitative computed tomography was used to measure changes in bone strength indices (bone strength index [BSI, mg2/mm4] and strength-strain index [SSIp, mm3]) and volumetric bone mineral density [vBMD, mg/cm3] at distal metaphyseal and diaphyseal regions of the femur and tibia, as well as calf and thigh muscle density (mg/cm3), and muscle cross-sectional area (MCSA, mm2), indices of skeletal muscle fat content and muscle force production, respectively. Results: After controlling for potential confounders, greater gains in femur BSI (44%, P<0.002), total femur vBMD (114%, P<0.04) and femur trabecular vBMD (306%, P<0.002) occurred in girls in the lowest versus the highest groups of baseline thigh muscle density. Greater gains in tibial BSI (25%, P<0.03) and trabecular vBMD (190%, P<0.002) were also observed in the lowest versus the highest baseline calf muscle density groups. Conclusion: Baseline muscle density is a significant predictor of changes in bone density and bone strength in young girls during a period of rapid skeletal development. NIH/NICHD #HD-050775.
Original language | English (US) |
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Pages (from-to) | 195-204 |
Number of pages | 10 |
Journal | Journal of Musculoskeletal Neuronal Interactions |
Volume | 14 |
Issue number | 2 |
State | Published - Jun 2014 |
Keywords
- Bone development
- Girls
- Peripheral quantitative computed tomography (pQCT)
- Skeletal muscle fat content
- Volumetric bone mineral density (vBMD)
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Physiology
- Orthopedics and Sports Medicine