Muscle density predicts changes in bone density and strength: A prospective study in girls

D. R. Laddu, Joshua Farr, V. R. Lee, R. M. Blew, C. Stump, L. Houtkooper, T. G. Lohman, S. B. Going

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We sought to determine whether muscle density, an index of skeletal muscle fat content, was predictive of 2-year changes in weight-bearing bone parameters in young girls. Methods: Two-year prospective data from 248 girls, aged 8-13 years at baseline. Peripheral quantitative computed tomography was used to measure changes in bone strength indices (bone strength index [BSI, mg2/mm4] and strength-strain index [SSIp, mm3]) and volumetric bone mineral density [vBMD, mg/cm3] at distal metaphyseal and diaphyseal regions of the femur and tibia, as well as calf and thigh muscle density (mg/cm3), and muscle cross-sectional area (MCSA, mm2), indices of skeletal muscle fat content and muscle force production, respectively. Results: After controlling for potential confounders, greater gains in femur BSI (44%, P<0.002), total femur vBMD (114%, P<0.04) and femur trabecular vBMD (306%, P<0.002) occurred in girls in the lowest versus the highest groups of baseline thigh muscle density. Greater gains in tibial BSI (25%, P<0.03) and trabecular vBMD (190%, P<0.002) were also observed in the lowest versus the highest baseline calf muscle density groups. Conclusion: Baseline muscle density is a significant predictor of changes in bone density and bone strength in young girls during a period of rapid skeletal development. NIH/NICHD #HD-050775.

Original languageEnglish (US)
Pages (from-to)195-204
Number of pages10
JournalJournal of Musculoskeletal Neuronal Interactions
Volume14
Issue number2
StatePublished - Jan 1 2014

Fingerprint

Bone Density
Prospective Studies
Muscles
Femur
Bone and Bones
Thigh
Skeletal Muscle
Fats
National Institute of Child Health and Human Development (U.S.)
Weight-Bearing
Tibia
Tomography

Keywords

  • Bone development
  • Girls
  • Peripheral quantitative computed tomography (pQCT)
  • Skeletal muscle fat content
  • Volumetric bone mineral density (vBMD)

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Physiology
  • Medicine(all)

Cite this

Laddu, D. R., Farr, J., Lee, V. R., Blew, R. M., Stump, C., Houtkooper, L., ... Going, S. B. (2014). Muscle density predicts changes in bone density and strength: A prospective study in girls. Journal of Musculoskeletal Neuronal Interactions, 14(2), 195-204.

Muscle density predicts changes in bone density and strength : A prospective study in girls. / Laddu, D. R.; Farr, Joshua; Lee, V. R.; Blew, R. M.; Stump, C.; Houtkooper, L.; Lohman, T. G.; Going, S. B.

In: Journal of Musculoskeletal Neuronal Interactions, Vol. 14, No. 2, 01.01.2014, p. 195-204.

Research output: Contribution to journalArticle

Laddu, DR, Farr, J, Lee, VR, Blew, RM, Stump, C, Houtkooper, L, Lohman, TG & Going, SB 2014, 'Muscle density predicts changes in bone density and strength: A prospective study in girls', Journal of Musculoskeletal Neuronal Interactions, vol. 14, no. 2, pp. 195-204.
Laddu, D. R. ; Farr, Joshua ; Lee, V. R. ; Blew, R. M. ; Stump, C. ; Houtkooper, L. ; Lohman, T. G. ; Going, S. B. / Muscle density predicts changes in bone density and strength : A prospective study in girls. In: Journal of Musculoskeletal Neuronal Interactions. 2014 ; Vol. 14, No. 2. pp. 195-204.
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