Muscle blood flow (MBF) was measured using the local 133Xenon injection method in patients with Duchenne type muscular dystrophy (6), limb girdle dystrophy (4), polymyositis (7), and in normal controls (11). Measurements were made at rest and during hyperemia induced by ischemic exercise and by histamine injection. Capillary diffusion capacity was measured with the 51Cr ethylene diaminetetra acetic acid (EDTA) method in 3 patients with Duchenne dystrophy and in 6 normal controls. Patients with Duchenne dystrophy had normal MBF during rest and during hyperemia after exercise and significantly increased MBF after histamine injection. The capillary diffusion capacity was higher than normal but not significantly. In limb girdle dystrophy MBF was normal, while in polymyositis it was significantly decreased in all 3 circulatory states. The relevance of the findings to the proposed ischemic etiology of Duchenne dystrophy is considered.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Neurology Neurosurgery and Psychiatry|
|State||Published - 1974|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Neuropsychology and Physiological Psychology