Abstract
This article reviews the indications for a muscle biopsy, and then gives a step-by-step description of the processes of muscle selection through to interpreting the biopsy report. The article aims to aid the clinician in preparing for a muscle biopsy procedure to avoid common pitfalls and obtain optimal results from this minimally invasive procedure. The basic anatomic structure of normal muscle is reviewed to provide a foundation for understanding common patterns of pathologic change observed in muscle disease and common and disease-specific histopathologic findings are presented, focusing on a select group of neuromuscular diseases.
Original language | English (US) |
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Pages (from-to) | 609-631 |
Number of pages | 23 |
Journal | Physical Medicine and Rehabilitation Clinics of North America |
Volume | 23 |
Issue number | 3 |
DOIs | |
State | Published - Aug 2012 |
Keywords
- Histopathology
- Muscle biopsy
- Myopathic
- Neurogenic atrophy
- Neuromuscular disease
ASJC Scopus subject areas
- Physical Therapy, Sports Therapy and Rehabilitation
- Rehabilitation