Mumps virus-specific immune response outcomes and sex-based differences in a cohort of healthy adolescents

Marguerite M. Riggenbach, Iana H. Haralambieva, Inna G. Ovsyannikova, Daniel J Schaid, Gregory A Poland, Richard B. Kennedy

Research output: Contribution to journalArticlepeer-review

Abstract

Despite high levels of MMR-II usage in the US, mumps outbreaks continue to occur. Evidence suggests that mumps vaccine-induced humoral immunity wanes over time. Relatively few studies have examined cell-mediated immunity or reported on sex-based differences. To better understand sex-based differences in the immune response to mumps vaccine, we measured neutralizing antibody titers and mumps-specific cytokine/chemokine responses in a cohort of 748 adolescents and young adults after two doses of MMR vaccine. We observed significantly higher neutralizing antibody titers in females than in males (120.8 IU/mL, 98.7 IU/mL, p = 0.038) but significantly higher secretion levels of MIP-1α, MIP-1β, TNFα, IL-6, IFNγ, and IL-1β in males compared to females. These data demonstrate that sex influences mumps-specific humoral and cell-mediated immune response outcomes, a phenomenon that should be considered during efforts to improve vaccines and prevent future outbreaks.

Original languageEnglish (US)
Article number108912
JournalClinical Immunology
Volume234
DOIs
StatePublished - Jan 2022

Keywords

  • Cellular immunity
  • Chemokine
  • Cytokine
  • MMR vaccine
  • Mumps
  • Sex-based differences

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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