Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain

Joseph Ross Mitchell, Stephen J. Karlik, Donald Lee, Aaron Fenster

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

MRI is a valuable tool in the diagnosis of multiple sclerosis (MS). Standard MR protocols for imaging MS produce proton density (PD) and T2 weighted images of the same slice in the brain. While these image pairs provide valuable information about MS lesions, they are two dimensional (2-D) while lesions are three dimensional (3-D). Furthermore, the vast amount of data produced in an MR exam for MS makes routine analysis and comparison of the image pairs difficult. Therefore, we have developed a computerized system which employs multi-spectral analysis techniques to allow interactive 3-D analysis of MR data by radiologists and neurologists. We have used our system to classify and analyze four MR exams of a chronic-progressive MS patient taken over an 18 month period. Comparison of volume renderings of classified white matter, grey matter and MS lesions at each exam date provide information about the changes in individual lesions, and total lesion burden. Analysis of the intensity distributions of large MS lesions reveals that they have a wide range of PD/T2 weighted intensities, and some contain a higher PD/longer T2 'core' perhaps corresponding to edema.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsMurray H. Loew
Place of PublicationBellingham, WA, United States
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages442-452
Number of pages11
Volume1898
ISBN (Print)0819411310
StatePublished - 1993
Externally publishedYes
EventMedical Imaging 1993: Image Processing - Newport Beach, CA, USA
Duration: Feb 14 1992Feb 19 1992

Other

OtherMedical Imaging 1993: Image Processing
CityNewport Beach, CA, USA
Period2/14/922/19/92

Fingerprint

lesions
brain
Brain
Protons
Visualization
Volume rendering
Magnetic resonance imaging
Spectrum analysis
Imaging techniques
edema
spectrum analysis

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Mitchell, J. R., Karlik, S. J., Lee, D., & Fenster, A. (1993). Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain. In M. H. Loew (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1898, pp. 442-452). Bellingham, WA, United States: Publ by Society of Photo-Optical Instrumentation Engineers.

Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain. / Mitchell, Joseph Ross; Karlik, Stephen J.; Lee, Donald; Fenster, Aaron.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Murray H. Loew. Vol. 1898 Bellingham, WA, United States : Publ by Society of Photo-Optical Instrumentation Engineers, 1993. p. 442-452.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mitchell, JR, Karlik, SJ, Lee, D & Fenster, A 1993, Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain. in MH Loew (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1898, Publ by Society of Photo-Optical Instrumentation Engineers, Bellingham, WA, United States, pp. 442-452, Medical Imaging 1993: Image Processing, Newport Beach, CA, USA, 2/14/92.
Mitchell JR, Karlik SJ, Lee D, Fenster A. Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain. In Loew MH, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1898. Bellingham, WA, United States: Publ by Society of Photo-Optical Instrumentation Engineers. 1993. p. 442-452
Mitchell, Joseph Ross ; Karlik, Stephen J. ; Lee, Donald ; Fenster, Aaron. / Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain. Proceedings of SPIE - The International Society for Optical Engineering. editor / Murray H. Loew. Vol. 1898 Bellingham, WA, United States : Publ by Society of Photo-Optical Instrumentation Engineers, 1993. pp. 442-452
@inproceedings{8227bc988a664f6cbaae9fc8eb8681ef,
title = "Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain",
abstract = "MRI is a valuable tool in the diagnosis of multiple sclerosis (MS). Standard MR protocols for imaging MS produce proton density (PD) and T2 weighted images of the same slice in the brain. While these image pairs provide valuable information about MS lesions, they are two dimensional (2-D) while lesions are three dimensional (3-D). Furthermore, the vast amount of data produced in an MR exam for MS makes routine analysis and comparison of the image pairs difficult. Therefore, we have developed a computerized system which employs multi-spectral analysis techniques to allow interactive 3-D analysis of MR data by radiologists and neurologists. We have used our system to classify and analyze four MR exams of a chronic-progressive MS patient taken over an 18 month period. Comparison of volume renderings of classified white matter, grey matter and MS lesions at each exam date provide information about the changes in individual lesions, and total lesion burden. Analysis of the intensity distributions of large MS lesions reveals that they have a wide range of PD/T2 weighted intensities, and some contain a higher PD/longer T2 'core' perhaps corresponding to edema.",
author = "Mitchell, {Joseph Ross} and Karlik, {Stephen J.} and Donald Lee and Aaron Fenster",
year = "1993",
language = "English (US)",
isbn = "0819411310",
volume = "1898",
pages = "442--452",
editor = "Loew, {Murray H.}",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "Publ by Society of Photo-Optical Instrumentation Engineers",

}

TY - GEN

T1 - Multispectral analysis and visualization of multiple sclerosis lesions in MR volumes of the brain

AU - Mitchell, Joseph Ross

AU - Karlik, Stephen J.

AU - Lee, Donald

AU - Fenster, Aaron

PY - 1993

Y1 - 1993

N2 - MRI is a valuable tool in the diagnosis of multiple sclerosis (MS). Standard MR protocols for imaging MS produce proton density (PD) and T2 weighted images of the same slice in the brain. While these image pairs provide valuable information about MS lesions, they are two dimensional (2-D) while lesions are three dimensional (3-D). Furthermore, the vast amount of data produced in an MR exam for MS makes routine analysis and comparison of the image pairs difficult. Therefore, we have developed a computerized system which employs multi-spectral analysis techniques to allow interactive 3-D analysis of MR data by radiologists and neurologists. We have used our system to classify and analyze four MR exams of a chronic-progressive MS patient taken over an 18 month period. Comparison of volume renderings of classified white matter, grey matter and MS lesions at each exam date provide information about the changes in individual lesions, and total lesion burden. Analysis of the intensity distributions of large MS lesions reveals that they have a wide range of PD/T2 weighted intensities, and some contain a higher PD/longer T2 'core' perhaps corresponding to edema.

AB - MRI is a valuable tool in the diagnosis of multiple sclerosis (MS). Standard MR protocols for imaging MS produce proton density (PD) and T2 weighted images of the same slice in the brain. While these image pairs provide valuable information about MS lesions, they are two dimensional (2-D) while lesions are three dimensional (3-D). Furthermore, the vast amount of data produced in an MR exam for MS makes routine analysis and comparison of the image pairs difficult. Therefore, we have developed a computerized system which employs multi-spectral analysis techniques to allow interactive 3-D analysis of MR data by radiologists and neurologists. We have used our system to classify and analyze four MR exams of a chronic-progressive MS patient taken over an 18 month period. Comparison of volume renderings of classified white matter, grey matter and MS lesions at each exam date provide information about the changes in individual lesions, and total lesion burden. Analysis of the intensity distributions of large MS lesions reveals that they have a wide range of PD/T2 weighted intensities, and some contain a higher PD/longer T2 'core' perhaps corresponding to edema.

UR - http://www.scopus.com/inward/record.url?scp=0027803239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027803239&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0027803239

SN - 0819411310

VL - 1898

SP - 442

EP - 452

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Loew, Murray H.

PB - Publ by Society of Photo-Optical Instrumentation Engineers

CY - Bellingham, WA, United States

ER -