Multiple, thin-walled cysts are one of the HRCT features of airspace enlargement with fibrosis

Yasutaka Watanabe, Yoshinori Kawabata, Tetsu Kanauchi, Eishin Hoshi, Kazuyoshi Kurashima, Shinichiro Koyama, Thomas V. Colby

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Purpose Airspace enlargement with fibrosis (AEF) has been identified pathologically as a smoking related change. We sought to identify the HRCT findings of AEF and search for distinguishing features from honeycombing. Materials and methods 50 patients (47 males; mean age 69) were evaluated. All had undergone lobectomy for lung cancer and had confirmed AEF and/or usual interstitial pneumonia (UIP) by pathological evaluation. HRCT findings were first evaluated preresection for resected lobes, and then correlated with the subsequent pathological findings in the resection specimens. Three groups were devised: one with AEF alone to determine the HRCT findings of AEF, a second with AEF and UIP and third with UIP alone. HRCT features of AEF and honeycombing were compared. Results There were 11 patients (10 male; mean age 69) with AEF alone, 24 patients (22 male; mean age 69) with AEF and UIP, and 15 patients (15 male; mean age 68) with UIP alone. The HRCT on the AEF alone showed subpleural (but not abutting the pleura) multiple thin-walled cysts (MTWCs) in 7 and reticular opacities in 3. The HRCT in AEF and UIP showed MTWCs in 10, reticular opacities in 17; and honeycombing in 5. Among these 35 patients with the pathological finding of AEF (with or without UIP), 17 showed MTWCs. The maximum cyst wall thickness of MTWCs (mean 0.81 mm) was significantly thinner than that of honeycombing (mean 1.56 mm). MTWCs did not locate in lung base and was distant from the pleura. HRCT findings correlated with gross findings on both cysts and honeycombing. No MTWCs were seen in the 15 patients with UIP, 8 of 15 had honeycombing on CT. Conclusions We confirmed that HRCT features of AEF were MTWCs and/or reticular opacities. MTWCs might be distinguished from those of honeycomb change. While we prefer the term MTWCs, these sorts of changes have probably been confused with/interpreted as honeycombing and/or empysema in the past.

Original languageEnglish (US)
Pages (from-to)986-992
Number of pages7
JournalEuropean Journal of Radiology
Volume84
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Airspace enlargement with fibrosis
  • HRCT
  • Smoking
  • Smoking-related interstitial lung disease
  • Usual interstitial pneumonia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Multiple, thin-walled cysts are one of the HRCT features of airspace enlargement with fibrosis'. Together they form a unique fingerprint.

  • Cite this

    Watanabe, Y., Kawabata, Y., Kanauchi, T., Hoshi, E., Kurashima, K., Koyama, S., & Colby, T. V. (2015). Multiple, thin-walled cysts are one of the HRCT features of airspace enlargement with fibrosis. European Journal of Radiology, 84(5), 986-992. https://doi.org/10.1016/j.ejrad.2015.01.015