Multiple system atrophy: A clinical and neuropathological perspective

Kiren Ubhi, Phillip Low, Eliezer Masliah

Research output: Contribution to journalReview article

91 Scopus citations

Abstract

Multiple system atrophy (MSA) is a neurodegenerative disease involving motor abnormalities that include akinesia, rigidity and postural instability. While improved diagnostic criteria have aided the accurate diagnosis of MSA, our understanding of the neuropathological aspects underlying MSA was bolstered by the identification of α-synuclein (α-syn) as the primary constituent of the abnormal protein aggregates observed in the brains of MSA patients. The generation of transgenic animal models of MSA coupled with an increasing understanding of the biochemical structure and function of α-syn has highlighted a number of key pathological pathways thought to underlie the neurodegeneration observed in MSA. This review summarizes key findings in the field, discusses current areas of debate, and describes current experimental approaches towards disease-modifying therapies.

Original languageEnglish (US)
Pages (from-to)581-590
Number of pages10
JournalTrends in neurosciences
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Neuroscience(all)

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